ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

3643

Symbol:

INSR

Full Name:

insulin receptor

Alias:

CD220|HHF5

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

19p13.3-p13.2

Physical Location:

7063265-7245010 on NC_000019.8, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		X02160
Fold Change:		0.64
P Value:		0.019

Dataset Information

Name:		12774316
Method:		Microarray
Tissue:		Temporal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed
Summary:		To identify candidate mechanisms for alcohol abuse, the expression of 12,626 genes was measured in postmortem temporal cortex from 11 subjects with a history of alcohol abuse or dependence, with or without other psychiatric diagnoses and compared pairwise with the expression in 11 nonalcoholic subjects matched for the other psychiatric diagnoses and demographics. Genes were defined to have altered expression in alcohol abuse if: 1) the gene showed decreased expression in at least 10 of 11 subjects with alcohol abuse, or showed increased expression in at least 10 of 11 subjects with this diagnosis compared to matched non-abusers (P<0.007, X2test); or 2) the difference in the mean abuser/non-abuser ratio for the gene from value of 1.0 was significant at P<0.05 (one sample t-test). In subjects with a history of alcohol abuse or dependence, 163 genes were changed significantly.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_000208.2	NP_000199.2	NC_000019.8 range: 7063265..7245010, complement
NM_001079817.1	NP_001073285.1	NC_000019.8 range: 7063265..7245010, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0010008	endosome membrane	Cellular Component	EXP (2986535)
GO:0005887	integral to plasma membrane	Cellular Component	TAS (2859121)
GO:0005886	plasma membrane	Cellular Component	TAS (9092559)
GO:0005886	plasma membrane	Cellular Component	EXP (2986535)
GO:0016020	membrane	Cellular Component	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0016740	transferase activity	Molecular Function	IEA
GO:0042169	SH2 domain binding	Molecular Function	IPI (8276809)
GO:0043548	phosphoinositide 3-kinase binding	Molecular Function	IPI (7537849\|8276809)
GO:0043559	insulin binding	Molecular Function	IDA (8440175)
GO:0043560	insulin receptor substrate binding	Molecular Function	IPI (7537849\|7559478)
GO:0051425	PTB domain binding	Molecular Function	IPI (7559478)
GO:0005009	insulin receptor activity	Molecular Function	IDA (8440175)
GO:0004714	transmembrane receptor protein tyrosine kinase activity	Molecular Function	IEA
GO:0004716	receptor signaling protein tyrosine kinase activity	Molecular Function	TAS (6849137)
GO:0004872	receptor activity	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0005066	transmembrane receptor protein tyrosine kinase signaling protein activity	Molecular Function	TAS (1607076)
GO:0004872	receptor activity	Molecular Function	TAS (1986371)
GO:0051290	protein heterotetramerization	Biological Process	IDA (1898103)
GO:0046777	protein amino acid autophosphorylation	Biological Process	IMP (7537849)
GO:0006468	protein amino acid phosphorylation	Biological Process	IEA
GO:0005975	carbohydrate metabolic process	Biological Process	TAS (2859121)
GO:0008286	insulin receptor signaling pathway	Biological Process	IDA (8440175)
GO:0007275	multicellular organismal development	Biological Process	TAS (7693131)
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	Biological Process	IEA
GO:0006091	generation of precursor metabolites and energy	Biological Process	TAS (2859121)
GO:0007165	signal transduction	Biological Process	TAS (6849137)