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Gene Information
Gene ID:3643
Full Name:insulin receptor
Organism:Homo sapiens (Human)
Genetic Location:19p13.3-p13.2
Physical Location:7063265-7245010 on NC_000019.8, complement
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:X02160
Fold Change:0.64
P Value:0.019
Dataset Information
Tissue:Temporal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed
Summary:To identify candidate mechanisms for alcohol abuse, the expression of 12,626 genes was measured in postmortem temporal cortex from 11 subjects with a history of alcohol abuse or dependence, with or without other psychiatric diagnoses and compared pairwise with the expression in 11 nonalcoholic subjects matched for the other psychiatric diagnoses and demographics. Genes were defined to have altered expression in alcohol abuse if: 1) the gene showed decreased expression in at least 10 of 11 subjects with alcohol abuse, or showed increased expression in at least 10 of 11 subjects with this diagnosis compared to matched non-abusers (P<0.007, X2test); or 2) the difference in the mean abuser/non-abuser ratio for the gene from value of 1.0 was significant at P<0.05 (one sample t-test). In subjects with a history of alcohol abuse or dependence, 163 genes were changed significantly.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_000208.2NP_000199.2NC_000019.8 range: 7063265..7245010, complement
NM_001079817.1NP_001073285.1NC_000019.8 range: 7063265..7245010, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0016021integral to membraneCellular ComponentIEA
GO:0010008endosome membraneCellular ComponentEXP (2986535)
GO:0005887integral to plasma membraneCellular ComponentTAS (2859121)
GO:0005886plasma membraneCellular ComponentTAS (9092559)
GO:0005886plasma membraneCellular ComponentEXP (2986535)
GO:0016020membraneCellular ComponentIEA
GO:0000166nucleotide bindingMolecular FunctionIEA
GO:0016740transferase activityMolecular FunctionIEA
GO:0042169SH2 domain bindingMolecular FunctionIPI (8276809)
GO:0043548phosphoinositide 3-kinase bindingMolecular FunctionIPI (7537849|8276809)
GO:0043559insulin bindingMolecular FunctionIDA (8440175)
GO:0043560insulin receptor substrate bindingMolecular FunctionIPI (7537849|7559478)
GO:0051425PTB domain bindingMolecular FunctionIPI (7559478)
GO:0005009insulin receptor activityMolecular FunctionIDA (8440175)
GO:0004714transmembrane receptor protein tyrosine kinase activityMolecular FunctionIEA
GO:0004716receptor signaling protein tyrosine kinase activityMolecular FunctionTAS (6849137)
GO:0004872receptor activityMolecular FunctionIEA
GO:0005524ATP bindingMolecular FunctionIEA
GO:0005066transmembrane receptor protein tyrosine kinase signaling protein activityMolecular FunctionTAS (1607076)
GO:0004872receptor activityMolecular FunctionTAS (1986371)
GO:0051290protein heterotetramerizationBiological ProcessIDA (1898103)
GO:0046777protein amino acid autophosphorylationBiological ProcessIMP (7537849)
GO:0006468protein amino acid phosphorylationBiological ProcessIEA
GO:0005975carbohydrate metabolic processBiological ProcessTAS (2859121)
GO:0008286insulin receptor signaling pathwayBiological ProcessIDA (8440175)
GO:0007275multicellular organismal developmentBiological ProcessTAS (7693131)
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathwayBiological ProcessIEA
GO:0006091generation of precursor metabolites and energyBiological ProcessTAS (2859121)
GO:0007165signal transductionBiological ProcessTAS (6849137)
Other Database Cross Links
NCBI Entrez Gene:3643
HuGE Navigator:3643