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Gene Information
Gene ID:6450
Full Name:SH3 domain binding glutamic acid-rich protein
Organism:Homo sapiens (Human)
Genetic Location:21q22.3
Physical Location:39739666-39809302 on NC_000021.7
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:X93498
Fold Change:0.63
P Value:0.0048
Dataset Information
Tissue:Temporal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed
Summary:To identify candidate mechanisms for alcohol abuse, the expression of 12,626 genes was measured in postmortem temporal cortex from 11 subjects with a history of alcohol abuse or dependence, with or without other psychiatric diagnoses and compared pairwise with the expression in 11 nonalcoholic subjects matched for the other psychiatric diagnoses and demographics. Genes were defined to have altered expression in alcohol abuse if: 1) the gene showed decreased expression in at least 10 of 11 subjects with alcohol abuse, or showed increased expression in at least 10 of 11 subjects with this diagnosis compared to matched non-abusers (P<0.007, X2test); or 2) the difference in the mean abuser/non-abuser ratio for the gene from value of 1.0 was significant at P<0.05 (one sample t-test). In subjects with a history of alcohol abuse or dependence, 163 genes were changed significantly.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_001001713.1NP_001001713.1NC_000021.7 range: 39739666..39809302
NM_007341.2NP_031367.1NC_000021.7 range: 39739666..39809302
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005737cytoplasmCellular ComponentIDA (16780588)
GO:0005070SH3/SH2 adaptor activityMolecular FunctionTAS (9050928)
GO:0006461protein complex assemblyBiological ProcessTAS (9050928)
Other Database Cross Links
NCBI Entrez Gene:6450
HuGE Navigator:6450