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Gene Information
Gene ID:23673
Symbol:STX12
Full Name:syntaxin 12
Alias:MGC51957|STX13|STX14
Organism:Homo sapiens (Human)
Chromosome:1
Genetic Location:1p35-p34.1
Physical Location:27972280-28023549 on NC_000001.9
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:AL035306
Fold Change:0.77
P Value:0.0098
Dataset Information
Name:12774316
Method:Microarray
Tissue:Temporal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed
Summary:To identify candidate mechanisms for alcohol abuse, the expression of 12,626 genes was measured in postmortem temporal cortex from 11 subjects with a history of alcohol abuse or dependence, with or without other psychiatric diagnoses and compared pairwise with the expression in 11 nonalcoholic subjects matched for the other psychiatric diagnoses and demographics. Genes were defined to have altered expression in alcohol abuse if: 1) the gene showed decreased expression in at least 10 of 11 subjects with alcohol abuse, or showed increased expression in at least 10 of 11 subjects with this diagnosis compared to matched non-abusers (P<0.007, X2test); or 2) the difference in the mean abuser/non-abuser ratio for the gene from value of 1.0 was significant at P<0.05 (one sample t-test). In subjects with a history of alcohol abuse or dependence, 163 genes were changed significantly.
Gene Information
Original ID1:STX12
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_177424.2NP_803173.1NC_000001.9 range: 27972280..28023549
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005794Golgi apparatusCellular ComponentIEA
GO:0045335phagocytic vesicleCellular ComponentIDA (15469992)
GO:0016020membraneCellular ComponentIEA
GO:0016021integral to membraneCellular ComponentIEA
GO:0045121membrane raftCellular ComponentIDA (15469992)
GO:0005484SNAP receptor activityMolecular FunctionIEA
GO:0033344cholesterol effluxBiological ProcessIDA (15469992)
GO:0016192vesicle-mediated transportBiological ProcessIEA
GO:0006886intracellular protein transportBiological ProcessIEA
GO:0050821protein stabilizationBiological ProcessIDA (15469992)
Other Database Cross Links
NCBI Entrez Gene:23673
HGNC:11430
Ensembl:ENSG00000117758
MIM:606892
HPRD:06059
HuGE Navigator:23673
dbSNP:STX12
GeneCard:STX12
AceView:STX12