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Gene Information
Gene ID:7010
Symbol:TEK
Full Name:TEK tyrosine kinase, endothelial (venous malformations, multiple cutaneous and mucosal)
Alias:CD202B|TIE-2|TIE2|VMCM|VMCM1
Organism:Homo sapiens (Human)
Chromosome:9
Genetic Location:9p21
Physical Location:27099285-27220171 on NC_000009.10
Gene Type:protein-coding
Orthologs:This gene has Mouse: 21687 ortholog(s) in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:L06139
Fold Change:0.77
P Value:0.0067
Dataset Information
Name:12774316
Method:Microarray
Tissue:Temporal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed
Summary:To identify candidate mechanisms for alcohol abuse, the expression of 12,626 genes was measured in postmortem temporal cortex from 11 subjects with a history of alcohol abuse or dependence, with or without other psychiatric diagnoses and compared pairwise with the expression in 11 nonalcoholic subjects matched for the other psychiatric diagnoses and demographics. Genes were defined to have altered expression in alcohol abuse if: 1) the gene showed decreased expression in at least 10 of 11 subjects with alcohol abuse, or showed increased expression in at least 10 of 11 subjects with this diagnosis compared to matched non-abusers (P<0.007, X2test); or 2) the difference in the mean abuser/non-abuser ratio for the gene from value of 1.0 was significant at P<0.05 (one sample t-test). In subjects with a history of alcohol abuse or dependence, 163 genes were changed significantly.
Gene Information
Original ID1:TEK
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_000459.3NP_000450.2NC_000009.10 range: 27099285..27220171
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0016021integral to membraneCellular ComponentIEA
GO:0016020membraneCellular ComponentIEA
GO:0005887integral to plasma membraneCellular ComponentTAS (8382358)
GO:0005886plasma membraneCellular ComponentEXP (14665640|14749497)
GO:0000166nucleotide bindingMolecular FunctionIEA
GO:0016301kinase activityMolecular FunctionIEA
GO:0016740transferase activityMolecular FunctionIEA
GO:0005524ATP bindingMolecular FunctionIEA
GO:0004872receptor activityMolecular FunctionTAS (10766762)
GO:0004872receptor activityMolecular FunctionIEA
GO:0004714transmembrane receptor protein tyrosine kinase activityMolecular FunctionTAS (8382358)
GO:0004713protein-tyrosine kinase activityMolecular FunctionIEA
GO:0007165signal transductionBiological ProcessTAS (8382358)
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathwayBiological ProcessTAS (8980225)
GO:0007267cell-cell signalingBiological ProcessTAS (8980225)
GO:0006468protein amino acid phosphorylationBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:7010
HGNC:11724
Ensembl:ENSG00000120156
MIM:600221
HPRD:02571
HuGE Navigator:7010
dbSNP:TEK
GeneCard:TEK
AceView:TEK