ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Tek

Full Name:

endothelial-specific receptor tyrosine kinase

Alias:

AA517024|Cd202b|Hyk|Tie2|tie-2

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

4 C5|4 43.6 cM

Physical Location:

94405990-94541629 on NC_000070.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 7010 Symbol (Name): TEK (TEK tyrosine kinase, endothelial (venous malformations, multiple cutaneous and mucosal))

Ortholog Status:

The human GeneID 7010 is also in human dataset(s).

Gene in Ethanol Study Datasets

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Caws2	Chronic Alcohol Withdrawal	4		33-51 (cM)	2.3	0.005	Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_013690.2	NP_038718.2	NC_000070.5 range: 94405990..94541629

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005886	plasma membrane	Cellular Component	EXP (14749497)
GO:0016021	integral to membrane	Cellular Component	ISM (8415706)
GO:0016020	membrane	Cellular Component	IEA
GO:0016740	transferase activity	Molecular Function	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0004872	receptor activity	Molecular Function	IEA
GO:0004714	transmembrane receptor protein tyrosine kinase activity	Molecular Function	IEA
GO:0004713	protein-tyrosine kinase activity	Molecular Function	IEA
GO:0004672	protein kinase activity	Molecular Function	IEA
GO:0016301	kinase activity	Molecular Function	IEA
GO:0030334	regulation of cell migration	Biological Process	IMP (9683559)
GO:0016337	cell-cell adhesion	Biological Process	IMP (9683559)
GO:0007160	cell-matrix adhesion	Biological Process	IMP (9683559)
GO:0006468	protein amino acid phosphorylation	Biological Process	IEA
GO:0045765	regulation of angiogenesis	Biological Process	IMP (9683559)