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Gene Information
Gene ID:3183
Full Name:heterogeneous nuclear ribonucleoprotein C (C1/C2)
Organism:Homo sapiens (Human)
Genetic Location:14q11.2
Physical Location:20747134-20807477 on NC_000014.7, complement
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:M16342
Fold Change:0.75
P Value:0.0023
Dataset Information
Tissue:Temporal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed
Summary:To identify candidate mechanisms for alcohol abuse, the expression of 12,626 genes was measured in postmortem temporal cortex from 11 subjects with a history of alcohol abuse or dependence, with or without other psychiatric diagnoses and compared pairwise with the expression in 11 nonalcoholic subjects matched for the other psychiatric diagnoses and demographics. Genes were defined to have altered expression in alcohol abuse if: 1) the gene showed decreased expression in at least 10 of 11 subjects with alcohol abuse, or showed increased expression in at least 10 of 11 subjects with this diagnosis compared to matched non-abusers (P<0.007, X2test); or 2) the difference in the mean abuser/non-abuser ratio for the gene from value of 1.0 was significant at P<0.05 (one sample t-test). In subjects with a history of alcohol abuse or dependence, 163 genes were changed significantly.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_001077442.1NP_001070910.1NC_000014.7 range: 20747134..20807477, complement
NM_001077443.1NP_001070911.1NC_000014.7 range: 20747134..20807477, complement
NM_004500.3NP_004491.2NC_000014.7 range: 20747134..20807477, complement
NM_031314.2NP_112604.2NC_000014.7 range: 20747134..20807477, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentIEA
GO:0005681spliceosomeCellular ComponentIDA (9731529)
GO:0000166nucleotide bindingMolecular FunctionIEA
GO:0003723RNA bindingMolecular FunctionNAS (9731529)
GO:0042802identical protein bindingMolecular FunctionIPI (16189514)
GO:0000398nuclear mRNA splicing, via spliceosomeBiological ProcessEXP (12226669)
GO:0000398nuclear mRNA splicing, via spliceosomeBiological ProcessIC (9731529)
GO:0008380RNA splicingBiological ProcessTAS (3110598)
Other Database Cross Links
NCBI Entrez Gene:3183
HuGE Navigator:3183