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Gene Information
Gene ID:4200
Symbol:ME2
Full Name:malic enzyme 2, NAD(+)-dependent, mitochondrial
Organism:Homo sapiens (Human)
Chromosome:18
Genetic Location:6p25-p24|18q21
Physical Location:46659432-46728257 on NC_000018.8
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:M55905
Fold Change:0.65
P Value:0.0009
Dataset Information
Name:12774316
Method:Microarray
Tissue:Temporal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed
Summary:To identify candidate mechanisms for alcohol abuse, the expression of 12,626 genes was measured in postmortem temporal cortex from 11 subjects with a history of alcohol abuse or dependence, with or without other psychiatric diagnoses and compared pairwise with the expression in 11 nonalcoholic subjects matched for the other psychiatric diagnoses and demographics. Genes were defined to have altered expression in alcohol abuse if: 1) the gene showed decreased expression in at least 10 of 11 subjects with alcohol abuse, or showed increased expression in at least 10 of 11 subjects with this diagnosis compared to matched non-abusers (P<0.007, X2test); or 2) the difference in the mean abuser/non-abuser ratio for the gene from value of 1.0 was significant at P<0.05 (one sample t-test). In subjects with a history of alcohol abuse or dependence, 163 genes were changed significantly.
Gene Information
Original ID1:ME2
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_002396.3NP_002387.1NC_000018.8 range: 46659432..46728257
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005739mitochondrionCellular ComponentIEA
GO:0005759mitochondrial matrixCellular ComponentIEA
GO:0004470malic enzyme activityMolecular FunctionIEA
GO:0046872metal ion bindingMolecular FunctionIEA
GO:0016619malate dehydrogenase (oxaloacetate-decarboxylating) activityMolecular FunctionIEA
GO:0016616oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptorMolecular FunctionIEA
GO:0016491oxidoreductase activityMolecular FunctionIEA
GO:0009055electron carrier activityMolecular FunctionTAS (1993674)
GO:0051287NAD bindingMolecular FunctionIEA
GO:0005488bindingMolecular FunctionIEA
GO:0004471malate dehydrogenase (decarboxylating) activityMolecular FunctionTAS (1993674)
GO:0006108malate metabolic processBiological ProcessIEA
GO:0008152metabolic processBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:4200
HGNC:6984
Ensembl:ENSG00000082212
MIM:154270
HPRD:01103
HuGE Navigator:4200
dbSNP:ME2
GeneCard:ME2
AceView:ME2