ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

GAMT

Full Name:

guanidinoacetate N-methyltransferase

Alias:

PIG2|TP53I2

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

19p13.3

Physical Location:

1348087-1352551 on NC_000019.8, complement

Gene Type:

protein-coding

Orthologs:

This gene has Rat: 25257 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		12774316
Method:		Microarray
Tissue:		Temporal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed
Summary:		To identify candidate mechanisms for alcohol abuse, the expression of 12,626 genes was measured in postmortem temporal cortex from 11 subjects with a history of alcohol abuse or dependence, with or without other psychiatric diagnoses and compared pairwise with the expression in 11 nonalcoholic subjects matched for the other psychiatric diagnoses and demographics. Genes were defined to have altered expression in alcohol abuse if: 1) the gene showed decreased expression in at least 10 of 11 subjects with alcohol abuse, or showed increased expression in at least 10 of 11 subjects with this diagnosis compared to matched non-abusers (P<0.007, X2test); or 2) the difference in the mean abuser/non-abuser ratio for the gene from value of 1.0 was significant at P<0.05 (one sample t-test). In subjects with a history of alcohol abuse or dependence, 163 genes were changed significantly.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005829	cytosol	Cellular Component	EXP (8651275)
GO:0008168	methyltransferase activity	Molecular Function	EXP (8651275)
GO:0008168	methyltransferase activity	Molecular Function	TAS (9325156)
GO:0016740	transferase activity	Molecular Function	IEA
GO:0030731	guanidinoacetate N-methyltransferase activity	Molecular Function	IEA
GO:0006601	creatine biosynthetic process	Biological Process	TAS (9325156)
GO:0006936	muscle contraction	Biological Process	TAS (8547310)