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Gene Information
Gene ID:2593
Full Name:guanidinoacetate N-methyltransferase
Organism:Homo sapiens (Human)
Genetic Location:19p13.3
Physical Location:1348087-1352551 on NC_000019.8, complement
Gene Type:protein-coding
Orthologs:This gene has Rat: 25257 ortholog(s) in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:AC005329
Fold Change:0.79
P Value:0.01
Dataset Information
Tissue:Temporal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed
Summary:To identify candidate mechanisms for alcohol abuse, the expression of 12,626 genes was measured in postmortem temporal cortex from 11 subjects with a history of alcohol abuse or dependence, with or without other psychiatric diagnoses and compared pairwise with the expression in 11 nonalcoholic subjects matched for the other psychiatric diagnoses and demographics. Genes were defined to have altered expression in alcohol abuse if: 1) the gene showed decreased expression in at least 10 of 11 subjects with alcohol abuse, or showed increased expression in at least 10 of 11 subjects with this diagnosis compared to matched non-abusers (P<0.007, X2test); or 2) the difference in the mean abuser/non-abuser ratio for the gene from value of 1.0 was significant at P<0.05 (one sample t-test). In subjects with a history of alcohol abuse or dependence, 163 genes were changed significantly.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_000156.4NP_000147.1NC_000019.8 range: 1348087..1352551, complement
NM_138924.1NP_620279.1NC_000019.8 range: 1348087..1352551, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005829cytosolCellular ComponentEXP (8651275)
GO:0008168methyltransferase activityMolecular FunctionEXP (8651275)
GO:0008168methyltransferase activityMolecular FunctionTAS (9325156)
GO:0016740transferase activityMolecular FunctionIEA
GO:0030731guanidinoacetate N-methyltransferase activityMolecular FunctionIEA
GO:0006601creatine biosynthetic processBiological ProcessTAS (9325156)
GO:0006936muscle contractionBiological ProcessTAS (8547310)
Other Database Cross Links
NCBI Entrez Gene:2593
HuGE Navigator:2593