ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Gamt

Full Name:

guanidinoacetate methyltransferase

Alias:

GMT

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

7q11

Physical Location:

10959989-10962719 on NC_005106.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 2593 Symbol (Name): GAMT (guanidinoacetate N-methyltransferase)

Ortholog Status:

The human GeneID 2593 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Gamt
Fold Change:		1.14
P Value:		0.004
Note:		Differential expression between ethanol and saccharin groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_012793.1	NP_036925.1	NC_005106.2 range: 10959989..10962719

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005575	cellular_component	Cellular Component	ND
GO:0030731	guanidinoacetate N-methyltransferase activity	Molecular Function	IDA (12069495\|15533043)
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	Molecular Function	IDA (15533043)
GO:0008168	methyltransferase activity	Molecular Function	IEA
GO:0030731	guanidinoacetate N-methyltransferase activity	Molecular Function	IEA
GO:0030731	guanidinoacetate N-methyltransferase activity	Molecular Function	NAS (3277179)
GO:0042803	protein homodimerization activity	Molecular Function	IDA (12079381)
GO:0016740	transferase activity	Molecular Function	IEA
GO:0040014	regulation of multicellular organism growth	Biological Process	IEA
GO:0040014	regulation of multicellular organism growth	Biological Process	ISS
GO:0046498	S-adenosylhomocysteine metabolic process	Biological Process	IDA (15533043)
GO:0009887	organ morphogenesis	Biological Process	ISS
GO:0009887	organ morphogenesis	Biological Process	IEA
GO:0007283	spermatogenesis	Biological Process	ISS
GO:0007283	spermatogenesis	Biological Process	IEA
GO:0006601	creatine biosynthetic process	Biological Process	TAS (12079381)
GO:0006601	creatine biosynthetic process	Biological Process	ISS
GO:0006601	creatine biosynthetic process	Biological Process	IEA
GO:0006601	creatine biosynthetic process	Biological Process	IDA (15533043)
GO:0046500	S-adenosylmethionine metabolic process	Biological Process	IDA (15533043)