ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

ITGAD

Full Name:

integrin, alpha D

Alias:

ADB2|CD11D|FLJ39841

Organism:

Homo sapiens (Human)

Chromosome:

16

Genetic Location:

16p11.2

Physical Location:

31312133-31345326 on NC_000016.8

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		U40279
Fold Change:		1.31
P Value:		0.049

Dataset Information

Name:		12774316
Method:		Microarray
Tissue:		Temporal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed
Summary:		To identify candidate mechanisms for alcohol abuse, the expression of 12,626 genes was measured in postmortem temporal cortex from 11 subjects with a history of alcohol abuse or dependence, with or without other psychiatric diagnoses and compared pairwise with the expression in 11 nonalcoholic subjects matched for the other psychiatric diagnoses and demographics. Genes were defined to have altered expression in alcohol abuse if: 1) the gene showed decreased expression in at least 10 of 11 subjects with alcohol abuse, or showed increased expression in at least 10 of 11 subjects with this diagnosis compared to matched non-abusers (P<0.007, X2test); or 2) the difference in the mean abuser/non-abuser ratio for the gene from value of 1.0 was significant at P<0.05 (one sample t-test). In subjects with a history of alcohol abuse or dependence, 163 genes were changed significantly.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_005353.2	NP_005344.2	NC_000016.8 range: 31312133..31345326

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0008305	integrin complex	Cellular Component	TAS
GO:0008305	integrin complex	Cellular Component	IEA
GO:0000287	magnesium ion binding	Molecular Function	IEA
GO:0004872	receptor activity	Molecular Function	IEA
GO:0005509	calcium ion binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IEA
GO:0007229	integrin-mediated signaling pathway	Biological Process	IEA
GO:0007160	cell-matrix adhesion	Biological Process	NAS
GO:0007155	cell adhesion	Biological Process	IEA
GO:0006955	immune response	Biological Process	NAS (9841932)
GO:0016337	cell-cell adhesion	Biological Process	NAS

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000156886

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: