ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

PHYH

Full Name:

phytanoyl-CoA 2-hydroxylase

Alias:

LN1|LNAP1|PAHX|PHYH1|RD

Organism:

Homo sapiens (Human)

Chromosome:

10

Genetic Location:

10pter-p11.2

Physical Location:

13359801-13382135 on NC_000010.9, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		AF023462
Fold Change:		0.71
P Value:		0.0017

Dataset Information

Name:		12774316
Method:		Microarray
Tissue:		Temporal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed
Summary:		To identify candidate mechanisms for alcohol abuse, the expression of 12,626 genes was measured in postmortem temporal cortex from 11 subjects with a history of alcohol abuse or dependence, with or without other psychiatric diagnoses and compared pairwise with the expression in 11 nonalcoholic subjects matched for the other psychiatric diagnoses and demographics. Genes were defined to have altered expression in alcohol abuse if: 1) the gene showed decreased expression in at least 10 of 11 subjects with alcohol abuse, or showed increased expression in at least 10 of 11 subjects with this diagnosis compared to matched non-abusers (P<0.007, X2test); or 2) the difference in the mean abuser/non-abuser ratio for the gene from value of 1.0 was significant at P<0.05 (one sample t-test). In subjects with a history of alcohol abuse or dependence, 163 genes were changed significantly.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_001037537.1	NP_001032626.1	NC_000010.9 range: 13359801..13382135, complement
NM_006214.3	NP_006205.1	NC_000010.9 range: 13359801..13382135, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005777	peroxisome	Cellular Component	TAS (8954107)
GO:0005506	iron ion binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (17353931)
GO:0048244	phytanoyl-CoA dioxygenase activity	Molecular Function	IEA
GO:0031418	L-ascorbic acid binding	Molecular Function	IEA
GO:0009055	electron carrier activity	Molecular Function	TAS (8954107)
GO:0007605	sensory perception of sound	Biological Process	IEA
GO:0007601	visual perception	Biological Process	IEA
GO:0007399	nervous system development	Biological Process	TAS (9326940)
GO:0006629	lipid metabolic process	Biological Process	TAS (8954107)
GO:0050896	response to stimulus	Biological Process	IEA

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000107537

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: