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Gene Information
Gene ID:36
Full Name:acyl-Coenzyme A dehydrogenase, short/branched chain
Organism:Homo sapiens (Human)
Genetic Location:10q26.13
Physical Location:124758418-124807795 on NC_000010.9
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:U12778
Fold Change:0.79
P Value:0.008
Dataset Information
Tissue:Temporal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed
Summary:To identify candidate mechanisms for alcohol abuse, the expression of 12,626 genes was measured in postmortem temporal cortex from 11 subjects with a history of alcohol abuse or dependence, with or without other psychiatric diagnoses and compared pairwise with the expression in 11 nonalcoholic subjects matched for the other psychiatric diagnoses and demographics. Genes were defined to have altered expression in alcohol abuse if: 1) the gene showed decreased expression in at least 10 of 11 subjects with alcohol abuse, or showed increased expression in at least 10 of 11 subjects with this diagnosis compared to matched non-abusers (P<0.007, X2test); or 2) the difference in the mean abuser/non-abuser ratio for the gene from value of 1.0 was significant at P<0.05 (one sample t-test). In subjects with a history of alcohol abuse or dependence, 163 genes were changed significantly.
Gene Information
Original ID1:ACADSB
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_001609.3NP_001600.1NC_000010.9 range: 124758418..124807795
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005739mitochondrionCellular ComponentTAS (7698750)
GO:0005759mitochondrial matrixCellular ComponentIEA
GO:0003995acyl-CoA dehydrogenase activityMolecular FunctionTAS (7698750)
GO:0009055electron carrier activityMolecular FunctionIEA
GO:0050660FAD bindingMolecular FunctionIEA
GO:0006091generation of precursor metabolites and energyBiological ProcessNR
GO:0006629lipid metabolic processBiological ProcessIEA
GO:0006631fatty acid metabolic processBiological ProcessTAS (7698750)
GO:0008152metabolic processBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:36
HuGE Navigator:36