ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

DPYD

Full Name:

dihydropyrimidine dehydrogenase

Alias:

DHP|DHPDHASE|DPD|MGC132008|MGC70799

Organism:

Homo sapiens (Human)

Chromosome:

1

Genetic Location:

1p22

Physical Location:

97315886-98159202 on NC_000001.9, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		U20938
Fold Change:		0.8
P Value:		0.045

Dataset Information

Name:		12774316
Method:		Microarray
Tissue:		Temporal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed
Summary:		To identify candidate mechanisms for alcohol abuse, the expression of 12,626 genes was measured in postmortem temporal cortex from 11 subjects with a history of alcohol abuse or dependence, with or without other psychiatric diagnoses and compared pairwise with the expression in 11 nonalcoholic subjects matched for the other psychiatric diagnoses and demographics. Genes were defined to have altered expression in alcohol abuse if: 1) the gene showed decreased expression in at least 10 of 11 subjects with alcohol abuse, or showed increased expression in at least 10 of 11 subjects with this diagnosis compared to matched non-abusers (P<0.007, X2test); or 2) the difference in the mean abuser/non-abuser ratio for the gene from value of 1.0 was significant at P<0.05 (one sample t-test). In subjects with a history of alcohol abuse or dependence, 163 genes were changed significantly.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_000110.3	NP_000101.2	NC_000001.9 range: 97315886..98159202, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IDA (1512248)
GO:0005829	cytosol	Cellular Component	EXP (8083224)
GO:0016491	oxidoreductase activity	Molecular Function	IEA
GO:0017113	dihydropyrimidine dehydrogenase (NADP+) activity	Molecular Function	EXP (8083224)
GO:0004152	dihydroorotate dehydrogenase activity	Molecular Function	IEA
GO:0017113	dihydropyrimidine dehydrogenase (NADP+) activity	Molecular Function	IDA (1512248)
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0050660	FAD binding	Molecular Function	IEA
GO:0051536	iron-sulfur cluster binding	Molecular Function	IEA
GO:0009055	electron carrier activity	Molecular Function	IEA
GO:0051539	4 iron, 4 sulfur cluster binding	Molecular Function	IEA
GO:0005506	iron ion binding	Molecular Function	IEA
GO:0005488	binding	Molecular Function	IEA
GO:0004159	dihydrouracil dehydrogenase (NAD+) activity	Molecular Function	EXP (8083224)
GO:0004158	dihydroorotate oxidase activity	Molecular Function	IEA
GO:0008152	metabolic process	Biological Process	IEA
GO:0006212	uracil catabolic process	Biological Process	IDA (1512248)
GO:0006207	'de novo' pyrimidine base biosynthetic process	Biological Process	IEA
GO:0006214	thymidine catabolic process	Biological Process	IDA (1512248)

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000188641

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: