ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

SMARCA5

Full Name:

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5

Alias:

ISWI|SNF2H|WCRF135|hISWI|hSNF2H

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

4q31.1-q31.2

Physical Location:

144654065-144694016 on NC_000004.10

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		12774316
Method:		Microarray
Tissue:		Temporal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed
Summary:		To identify candidate mechanisms for alcohol abuse, the expression of 12,626 genes was measured in postmortem temporal cortex from 11 subjects with a history of alcohol abuse or dependence, with or without other psychiatric diagnoses and compared pairwise with the expression in 11 nonalcoholic subjects matched for the other psychiatric diagnoses and demographics. Genes were defined to have altered expression in alcohol abuse if: 1) the gene showed decreased expression in at least 10 of 11 subjects with alcohol abuse, or showed increased expression in at least 10 of 11 subjects with this diagnosis compared to matched non-abusers (P<0.007, X2test); or 2) the difference in the mean abuser/non-abuser ratio for the gene from value of 1.0 was significant at P<0.05 (one sample t-test). In subjects with a history of alcohol abuse or dependence, 163 genes were changed significantly.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_003601.2	NP_003592.2	NC_000004.10 range: 144654065..144694016

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IDA (12972596)
GO:0000793	condensed chromosome	Cellular Component	IDA (12972596)
GO:0031213	RSF complex	Cellular Component	IPI (9836642)
GO:0005654	nucleoplasm	Cellular Component	TAS (9730600)
GO:0016887	ATPase activity	Molecular Function	IDA (12972596)
GO:0031491	nucleosome binding	Molecular Function	IEA
GO:0042393	histone binding	Molecular Function	IDA (12972596)
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IDA (12972596)
GO:0004386	helicase activity	Molecular Function	TAS (9730600)
GO:0003702	RNA polymerase II transcription factor activity	Molecular Function	TAS (9730600)
GO:0003677	DNA binding	Molecular Function	IDA (12972596)
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0016584	nucleosome positioning	Biological Process	IDA (9836642)
GO:0006357	regulation of transcription from RNA polymerase II promoter	Biological Process	TAS (9730600)
GO:0006352	transcription initiation	Biological Process	IDA (9836642)
GO:0006334	nucleosome assembly	Biological Process	IDA (12972596)
GO:0043044	ATP-dependent chromatin remodeling	Biological Process	IEA