ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

USP4

Full Name:

ubiquitin specific peptidase 4 (proto-oncogene)

Alias:

MGC149848|MGC149849|UNP|Unph

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

3p21.3

Physical Location:

49289996-49352518 on NC_000003.10, complement

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 22258 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		12774316
Method:		Microarray
Tissue:		Temporal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed
Summary:		To identify candidate mechanisms for alcohol abuse, the expression of 12,626 genes was measured in postmortem temporal cortex from 11 subjects with a history of alcohol abuse or dependence, with or without other psychiatric diagnoses and compared pairwise with the expression in 11 nonalcoholic subjects matched for the other psychiatric diagnoses and demographics. Genes were defined to have altered expression in alcohol abuse if: 1) the gene showed decreased expression in at least 10 of 11 subjects with alcohol abuse, or showed increased expression in at least 10 of 11 subjects with this diagnosis compared to matched non-abusers (P<0.007, X2test); or 2) the difference in the mean abuser/non-abuser ratio for the gene from value of 1.0 was significant at P<0.05 (one sample t-test). In subjects with a history of alcohol abuse or dependence, 163 genes were changed significantly.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	TAS (8183569)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005764	lysosome	Cellular Component	TAS (9827704)
GO:0004197	cysteine-type endopeptidase activity	Molecular Function	TAS (9464533)
GO:0004221	ubiquitin thiolesterase activity	Molecular Function	IEA
GO:0008234	cysteine-type peptidase activity	Molecular Function	IEA
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IEA
GO:0006512	ubiquitin cycle	Biological Process	IEA