ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Usp4

Full Name:

ubiquitin specific peptidase 4 (proto-oncogene)

Alias:

F730026I20Rik|KIAA4155|Unp|mKIAA4155

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

9 F2|9 60.0 cM

Physical Location:

108250198-108294856 on NC_000075.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 7375 Symbol (Name): USP4 (ubiquitin specific peptidase 4 (proto-oncogene))

Ortholog Status:

The human GeneID 7375 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Usp4
Fold Change:		1.62
Note:		Significantly regulated by ethanol in cortical neurons

Gene Information

Original ID1:		Usp4
Fold Change:		1.42
Note:		Significantly regulated in cortical neurons treated with both ethanol and nicotine

Dataset Information

Name:		17295719
Method:		Microarray
Tissue:		Cultured fetal mouse cortical neurons
Phenotype:		Ethanol response
Publication:		Wang et al. Alcohol Clin Exp Res. (2007) Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. PubMed
Summary:		By using cultured fetal mouse cortical neurons as a model system, we sought to identify genes and pathways that are modulated in the cells by ethanol, nicotine, or both. METHODS: Primary cerebral cortical cultures were prepared from the brains of 14-day-old C57BL/6 mouse fetuses and exposed to ethanol (75 mM), nicotine (0.1 mM), or both for 5 consecutive days. A homeostatic pathway-focused microarray consisting of 638 sequence-verified genes was used to measure transcripts differentially regulated by ethanol, nicotine, or both in 5 drug-treated cortical neuron samples and 5 control samples. We identified 65, 111, and 81 significantly regulated genes in the ethanol, nicotine, and ethanol/nicotine-treated neurons, respectively. A gene was considered to be significantly regulated if (1) the fold change was 20% greater or less compared with the controls and (2) the difference was p<0.05 by Student's t-test.

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Etact2	Alcohol Stimulated Activity	9	61	51-71 (cM)	3.6	4.30E-05	Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_011678.2	NP_035808.2	NC_000075.5 range: 108250198..108294856

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IEA
GO:0004221	ubiquitin thiolesterase activity	Molecular Function	IEA
GO:0008233	peptidase activity	Molecular Function	IEA
GO:0008234	cysteine-type peptidase activity	Molecular Function	IEA
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IEA
GO:0006512	ubiquitin cycle	Biological Process	IEA