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Gene Information
Gene ID:22258
Symbol:Usp4
Full Name:ubiquitin specific peptidase 4 (proto-oncogene)
Alias:F730026I20Rik|KIAA4155|Unp|mKIAA4155
Organism:Mus musculus (Mouse)
Chromosome:9
Genetic Location:9 F2|9 60.0 cM
Physical Location:108250198-108294856 on NC_000075.5
Gene Type:protein-coding
Human Ortholog:GeneID: 7375    Symbol (Name): USP4 (ubiquitin specific peptidase 4 (proto-oncogene))
Ortholog Status:The human GeneID 7375 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Usp4
Fold Change:1.62
Note:Significantly regulated by ethanol in cortical neurons
Gene Information
Original ID1:Usp4
Fold Change:1.42
Note:Significantly regulated in cortical neurons treated with both ethanol and nicotine
Dataset Information
Name:17295719
Method:Microarray
Tissue:Cultured fetal mouse cortical neurons
Phenotype:Ethanol response
Publication:Wang et al. Alcohol Clin Exp Res. (2007) Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. PubMed
Summary:By using cultured fetal mouse cortical neurons as a model system, we sought to identify genes and pathways that are modulated in the cells by ethanol, nicotine, or both. METHODS: Primary cerebral cortical cultures were prepared from the brains of 14-day-old C57BL/6 mouse fetuses and exposed to ethanol (75 mM), nicotine (0.1 mM), or both for 5 consecutive days. A homeostatic pathway-focused microarray consisting of 638 sequence-verified genes was used to measure transcripts differentially regulated by ethanol, nicotine, or both in 5 drug-treated cortical neuron samples and 5 control samples. We identified 65, 111, and 81 significantly regulated genes in the ethanol, nicotine, and ethanol/nicotine-treated neurons, respectively. A gene was considered to be significantly regulated if (1) the fold change was 20% greater or less compared with the controls and (2) the difference was p<0.05 by Student's t-test.
QTL Information
QTLPhenotypeChrPeak (cM)LODP ValueRangeStatusQTL Link
Etact2Alcohol Stimulated Activity96151-71 (cM)3.64.30E-05SignificantPARC
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_011678.2NP_035808.2NC_000075.5 range: 108250198..108294856
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentIEA
GO:0004221ubiquitin thiolesterase activityMolecular FunctionIEA
GO:0008233peptidase activityMolecular FunctionIEA
GO:0008234cysteine-type peptidase activityMolecular FunctionIEA
GO:0016787hydrolase activityMolecular FunctionIEA
GO:0006511ubiquitin-dependent protein catabolic processBiological ProcessIEA
GO:0006512ubiquitin cycleBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:22258
MGI:
Ensembl:ENSMUSG00000032612
dbSNP:Usp4
AceView:Usp4