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Gene Information
Gene ID:2323
Symbol:FLT3LG
Full Name:fms-related tyrosine kinase 3 ligand
Alias:FL
Organism:Homo sapiens (Human)
Chromosome:19
Genetic Location:19q13.3
Physical Location:54669297-54681299 on NC_000019.8
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:U03858
Fold Change:2.34
P Value:0.0054
Dataset Information
Name:12774316
Method:Microarray
Tissue:Temporal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed
Summary:To identify candidate mechanisms for alcohol abuse, the expression of 12,626 genes was measured in postmortem temporal cortex from 11 subjects with a history of alcohol abuse or dependence, with or without other psychiatric diagnoses and compared pairwise with the expression in 11 nonalcoholic subjects matched for the other psychiatric diagnoses and demographics. Genes were defined to have altered expression in alcohol abuse if: 1) the gene showed decreased expression in at least 10 of 11 subjects with alcohol abuse, or showed increased expression in at least 10 of 11 subjects with this diagnosis compared to matched non-abusers (P<0.007, X2test); or 2) the difference in the mean abuser/non-abuser ratio for the gene from value of 1.0 was significant at P<0.05 (one sample t-test). In subjects with a history of alcohol abuse or dependence, 163 genes were changed significantly.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_001459.2NP_001450.2NC_000019.8 range: 54669297..54681299
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005576extracellular regionCellular ComponentIEA
GO:0005615extracellular spaceCellular ComponentIEA
GO:0005625soluble fractionCellular ComponentTAS (8180375)
GO:0005886plasma membraneCellular ComponentIEA
GO:0016021integral to membraneCellular ComponentIEA
GO:0005125cytokine activityMolecular FunctionIEA
GO:0007165signal transductionBiological ProcessTAS (8180375)
GO:0008284positive regulation of cell proliferationBiological ProcessTAS (8145851)
Other Database Cross Links
NCBI Entrez Gene:2323
HGNC:3766
Ensembl:ENSG00000090554
MIM:600007
HPRD:02477
HuGE Navigator:2323
dbSNP:FLT3LG
GeneCard:FLT3LG
AceView:FLT3LG