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Gene Information
Gene ID:9311
Symbol:ACCN3
Full Name:amiloride-sensitive cation channel 3
Alias:ASIC3|DRASIC|SLNAC1|TNaC1
Organism:Homo sapiens (Human)
Chromosome:7
Genetic Location:7q35
Physical Location:150376884-150380773 on NC_000007.12
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:AB010575
Fold Change:2.07
P Value:0.01
Dataset Information
Name:12774316
Method:Microarray
Tissue:Temporal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed
Summary:To identify candidate mechanisms for alcohol abuse, the expression of 12,626 genes was measured in postmortem temporal cortex from 11 subjects with a history of alcohol abuse or dependence, with or without other psychiatric diagnoses and compared pairwise with the expression in 11 nonalcoholic subjects matched for the other psychiatric diagnoses and demographics. Genes were defined to have altered expression in alcohol abuse if: 1) the gene showed decreased expression in at least 10 of 11 subjects with alcohol abuse, or showed increased expression in at least 10 of 11 subjects with this diagnosis compared to matched non-abusers (P<0.007, X2test); or 2) the difference in the mean abuser/non-abuser ratio for the gene from value of 1.0 was significant at P<0.05 (one sample t-test). In subjects with a history of alcohol abuse or dependence, 163 genes were changed significantly.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_004769.2NP_004760.1NC_000007.12 range: 150376884..150380773
NM_020321.2NP_064717.1NC_000007.12 range: 150376884..150380773
NM_020322.2NP_064718.1NC_000007.12 range: 150376884..150380773
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005737cytoplasmCellular ComponentIEA
GO:0005886plasma membraneCellular ComponentTAS (9744806)
GO:0005887integral to plasma membraneCellular ComponentTAS (9571199)
GO:0015280amiloride-sensitive sodium channel activityMolecular FunctionIEA
GO:0031402sodium ion bindingMolecular FunctionIEA
GO:0006811ion transportBiological ProcessIEA
GO:0006814sodium ion transportBiological ProcessIEA
GO:0007165signal transductionBiological ProcessTAS (9744806)
GO:0007600sensory perceptionBiological ProcessTAS (9744806)
Other Database Cross Links
NCBI Entrez Gene:9311
HGNC:101
Ensembl:
MIM:611741
HPRD:10626
HuGE Navigator:9311
dbSNP:ACCN3
GeneCard:ACCN3
AceView:ACCN3