| Gene Information |
| Gene ID: | | 11145 |
| Symbol: | | HRASLS3 |
| Full Name: | | HRAS-like suppressor 3 |
| Alias: | | H-REV107-1|HREV107|HREV107-3|MGC118754 |
| Organism: | | Homo sapiens (Human) |
| Chromosome: | | 11 |
| Genetic Location: | | 11q12.3-q13.1 |
| Physical Location: | | 63098824-63138470 on NC_000011.8, complement |
| Gene Type: | | protein-coding |
| Orthologs: | | This gene has no orthologs in other dataset(s). |
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| Gene in Ethanol Study Datasets |
| Gene Information | | Original ID1: | | AI375733 | | Fold Change: | | -1.4, -1.6 | | Note: | | Differential Expression on the cDNA array (two fold changes are from two case groups) |
| | Dataset Information | | Name: | | 11141048 | | Method: | | Microarray | | Tissue: | | Frontal cortex | | Phenotype: | | Alcohol dependence (AD)/Alcohol abuse/Alcoholism | | Publication: | | Lewohl et al. Alcohol Clin Exp Res. (2000) Gene expression in human alcoholism: microarray analysis of frontal cortex. PubMed | | Summary: | | RNA was extracted from postmortem samples of superior frontal cortex of alcoholics and nonalcoholics. Relative levels of RNA were determined by array techniques. This study used both cDNA and oligonucleotide microarrays to provide coverage of a large number of genes and to allow cross-validation for those genes represented on both types of arrays. Expression levels were determined for over 4000 genes and 163 of these were found to differ by 40% or more between alcoholics and nonalcoholics. |
| | Gene Information | | Original ID1: | | X92814 | | Fold Change: | | 0.66 | | P Value: | | 0.0052 |
| | Dataset Information | | Name: | | 12774316 | | Method: | | Microarray | | Tissue: | | Temporal cortex | | Phenotype: | | Alcohol dependence (AD)/Alcohol abuse/Alcoholism | | Publication: | | Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed | | Summary: | | To identify candidate mechanisms for alcohol abuse, the expression of 12,626 genes was measured in postmortem temporal cortex from 11 subjects with a history of alcohol abuse or dependence, with or without other psychiatric diagnoses and compared pairwise with the expression in 11 nonalcoholic subjects matched for the other psychiatric diagnoses and demographics. Genes were defined to have altered expression in alcohol abuse if: 1) the gene showed decreased expression in at least 10 of 11 subjects with alcohol abuse, or showed increased expression in at least 10 of 11 subjects with this diagnosis compared to matched non-abusers (P<0.007, X2test); or 2) the difference in the mean abuser/non-abuser ratio for the gene from value of 1.0 was significant at P<0.05 (one sample t-test). In subjects with a history of alcohol abuse or dependence, 163 genes were changed significantly. |
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| Gene Refseq Sequence Annotation |
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| Gene Ontology (GO) Annotation |
| GO ID | GO Term | Category | Evidence (PubMed) | |
| GO:0005575 | cellular_component | Cellular Component | ND | |
| GO:0016020 | membrane | Cellular Component | IEA | |
| GO:0016021 | integral to membrane | Cellular Component | IEA | |
| GO:0003674 | molecular_function | Molecular Function | ND (9771974) | |
| GO:0005515 | protein binding | Molecular Function | IPI (17374643) | |
| GO:0008150 | biological_process | Biological Process | ND | |
| GO:0045786 | negative regulation of cell cycle | Biological Process | IEA | |
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| Other Database Cross Links |
| NCBI Entrez Gene: | | 11145 |
| HGNC: | | 17825 |
| Ensembl: | | ENSG00000176485 |
| MIM: | | |
| HPRD: | | 13671 |
| HuGE Navigator: | | 11145 |
| dbSNP: | | HRASLS3 |
| GeneCard: | | HRASLS3 |
| AceView: | | HRASLS3 |
