| Gene Information |
| Gene ID: | | 7050 |
| Symbol: | | TGIF1 |
| Full Name: | | TGFB-induced factor homeobox 1 |
| Alias: | | HPE4|MGC39747|MGC5066|TGIF |
| Organism: | | Homo sapiens (Human) |
| Chromosome: | | 18 |
| Genetic Location: | | 18p11.3 |
| Physical Location: | | 3402071-3448408 on NC_000018.8 |
| Gene Type: | | protein-coding |
| Orthologs: | | This gene has no orthologs in other dataset(s). |
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| Gene in Ethanol Study Datasets |
| Gene Information | | Original ID1: | | X89750 | | Fold Change: | | 0.64 | | P Value: | | 0.0072 |
| | Dataset Information | | Name: | | 12774316 | | Method: | | Microarray | | Tissue: | | Temporal cortex | | Phenotype: | | Alcohol dependence (AD)/Alcohol abuse/Alcoholism | | Publication: | | Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed | | Summary: | | To identify candidate mechanisms for alcohol abuse, the expression of 12,626 genes was measured in postmortem temporal cortex from 11 subjects with a history of alcohol abuse or dependence, with or without other psychiatric diagnoses and compared pairwise with the expression in 11 nonalcoholic subjects matched for the other psychiatric diagnoses and demographics. Genes were defined to have altered expression in alcohol abuse if: 1) the gene showed decreased expression in at least 10 of 11 subjects with alcohol abuse, or showed increased expression in at least 10 of 11 subjects with this diagnosis compared to matched non-abusers (P<0.007, X2test); or 2) the difference in the mean abuser/non-abuser ratio for the gene from value of 1.0 was significant at P<0.05 (one sample t-test). In subjects with a history of alcohol abuse or dependence, 163 genes were changed significantly. |
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| Gene Refseq Sequence Annotation |
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| Gene Ontology (GO) Annotation |
| GO ID | GO Term | Category | Evidence (PubMed) | |
| GO:0005634 | nucleus | Cellular Component | IEA | |
| GO:0003700 | transcription factor activity | Molecular Function | TAS (8537382) | |
| GO:0003714 | transcription corepressor activity | Molecular Function | TAS (10764806) | |
| GO:0005515 | protein binding | Molecular Function | IPI (17353931) | |
| GO:0043565 | sequence-specific DNA binding | Molecular Function | IEA | |
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | Biological Process | TAS (10764806) | |
| GO:0006355 | regulation of transcription, DNA-dependent | Biological Process | IEA | |
| GO:0007275 | multicellular organismal development | Biological Process | TAS (8537382) | |
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| Other Database Cross Links |
| NCBI Entrez Gene: | | 7050 |
| HGNC: | | 11776 |
| Ensembl: | | ENSG00000177426 |
| MIM: | | 602630 |
| HPRD: | | 04023 |
| HuGE Navigator: | | 7050 |
| dbSNP: | | TGIF1 |
| GeneCard: | | TGIF1 |
| AceView: | | TGIF1 |
