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Gene Information
Gene ID:10632
Symbol:ATP5L
Full Name:ATP synthase, H+ transporting, mitochondrial F0 complex, subunit G
Alias:ATP5JG
Organism:Homo sapiens (Human)
Chromosome:11
Genetic Location:11q23.3
Physical Location:117777313-117785771 on NC_000011.8
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:AA917672
Fold Change:0.74
P Value:0.023
Dataset Information
Name:12774316
Method:Microarray
Tissue:Temporal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed
Summary:To identify candidate mechanisms for alcohol abuse, the expression of 12,626 genes was measured in postmortem temporal cortex from 11 subjects with a history of alcohol abuse or dependence, with or without other psychiatric diagnoses and compared pairwise with the expression in 11 nonalcoholic subjects matched for the other psychiatric diagnoses and demographics. Genes were defined to have altered expression in alcohol abuse if: 1) the gene showed decreased expression in at least 10 of 11 subjects with alcohol abuse, or showed increased expression in at least 10 of 11 subjects with this diagnosis compared to matched non-abusers (P<0.007, X2test); or 2) the difference in the mean abuser/non-abuser ratio for the gene from value of 1.0 was significant at P<0.05 (one sample t-test). In subjects with a history of alcohol abuse or dependence, 163 genes were changed significantly.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_006476.4NP_006467.4NC_000011.8 range: 117777313..117785771
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0016020membraneCellular ComponentIEA
GO:0005739mitochondrionCellular ComponentIEA
GO:0005753mitochondrial proton-transporting ATP synthase complexCellular ComponentIDA (12110673)
GO:0045263proton-transporting ATP synthase complex, coupling factor F(o)Cellular ComponentIEA
GO:0016469proton-transporting two-sector ATPase complexCellular ComponentIEA
GO:0046933hydrogen ion transporting ATP synthase activity, rotational mechanismMolecular FunctionIEA
GO:0046872metal ion bindingMolecular FunctionIEA
GO:0016887ATPase activityMolecular FunctionIDA (12110673)
GO:0005515protein bindingMolecular FunctionIPI (17353931)
GO:0046961hydrogen ion transporting ATPase activity, rotational mechanismMolecular FunctionIEA
GO:0015992proton transportBiological ProcessIEA
GO:0015986ATP synthesis coupled proton transportBiological ProcessIEA
GO:0006811ion transportBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:10632
HGNC:14247
Ensembl:ENSG00000167283
MIM:
HPRD:09815
HuGE Navigator:10632
dbSNP:ATP5L
GeneCard:ATP5L
AceView:ATP5L