ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

KDR

Full Name:

kinase insert domain receptor (a type III receptor tyrosine kinase)

Alias:

CD309|FLK1|VEGFR|VEGFR2

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

4q11-q12

Physical Location:

55639405-55686518 on NC_000004.10, complement

Gene Type:

protein-coding

Orthologs:

This gene has Rat: 25589 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		12774316
Method:		Microarray
Tissue:		Temporal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed
Summary:		To identify candidate mechanisms for alcohol abuse, the expression of 12,626 genes was measured in postmortem temporal cortex from 11 subjects with a history of alcohol abuse or dependence, with or without other psychiatric diagnoses and compared pairwise with the expression in 11 nonalcoholic subjects matched for the other psychiatric diagnoses and demographics. Genes were defined to have altered expression in alcohol abuse if: 1) the gene showed decreased expression in at least 10 of 11 subjects with alcohol abuse, or showed increased expression in at least 10 of 11 subjects with this diagnosis compared to matched non-abusers (P<0.007, X2test); or 2) the difference in the mean abuser/non-abuser ratio for the gene from value of 1.0 was significant at P<0.05 (one sample t-test). In subjects with a history of alcohol abuse or dependence, 163 genes were changed significantly.

Gene Information

Original ID1:

KDR

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_002253.1	NP_002244.1	NC_000004.10 range: 55639405..55686518, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005887	integral to plasma membrane	Cellular Component	TAS (1656371)
GO:0016020	membrane	Cellular Component	IEA
GO:0016740	transferase activity	Molecular Function	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (16530705\|17222790)
GO:0005021	vascular endothelial growth factor receptor activity	Molecular Function	TAS (1417831)
GO:0004872	receptor activity	Molecular Function	IEA
GO:0006468	protein amino acid phosphorylation	Biological Process	IEA
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	Biological Process	TAS (1417831)
GO:0007275	multicellular organismal development	Biological Process	IEA
GO:0001525	angiogenesis	Biological Process	IEA
GO:0030154	cell differentiation	Biological Process	IEA