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Gene Information
Gene ID:25589
Symbol:Kdr
Full Name:kinase insert domain protein receptor
Alias:MGC93590|Vegfr-2
Organism:Rattus norvegicus (Rat)
Chromosome:14
Gene Type:protein-coding
Human Ortholog:GeneID: 3791    Symbol (Name): KDR (kinase insert domain receptor (a type III receptor tyrosine kinase))
Ortholog Status:The human GeneID 3791 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Kdr
Fold Change:-1.5
Tissue:Amygdala
Dataset Information
Name:17517326
Method:Microarray
Tissue:Nucleus accumbens, amygdala, frontal cortex, caudate-putamen, and hippocampus
Phenotype:Alcohol-preferring, alcohol-nonpreferring
Publication:Kimpel et al. Alcohol. (2007) Functional gene expression differences between inbred alcohol-preferring and -non-preferring rats in five brain regions. PubMed
Summary:The objective of this study was to determine if there are innate differences in gene expression in selected CNS regions between inbred alcohol-preferring (iP) and -non-preferring (iNP) rats. Gene expression was determined in the nucleus accumbens (ACB), amygdala (AMYG), frontal cortex (FC), caudate-putamen (CPU), and hippocampus (HIPP) of alcohol-naive adult male iP and iNP rats, using Affymetrix Rat Genome U34A microarrays (n = 6/strain). Using Linear Modeling for Microarray Analysis with a false discovery rate threshold of 0.1, there were 16 genes with differential expression in the ACB, 54 in the AMYG, 8 in the FC, 24 in the CPU, and 21 in the HIPP. All the fold change are iP vs. iNP fold change.
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0016021integral to membraneCellular ComponentIEA
GO:0016020membraneCellular ComponentIEA
GO:0000166nucleotide bindingMolecular FunctionIEA
GO:0019838growth factor bindingMolecular FunctionISS
GO:0019838growth factor bindingMolecular FunctionIMP (9442048)
GO:0016740transferase activityMolecular FunctionIEA
GO:0005524ATP bindingMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionISS
GO:0005021vascular endothelial growth factor receptor activityMolecular FunctionISS
GO:0005021vascular endothelial growth factor receptor activityMolecular FunctionIMP (9442048|15785231)
GO:0005021vascular endothelial growth factor receptor activityMolecular FunctionIEA
GO:0004872receptor activityMolecular FunctionIEA
GO:0045446endothelial cell differentiationBiological ProcessISS
GO:0045766positive regulation of angiogenesisBiological ProcessIDA (15951738)
GO:0048010vascular endothelial growth factor receptor signaling pathwayBiological ProcessIMP (9442048)
GO:0048010vascular endothelial growth factor receptor signaling pathwayBiological ProcessISS
GO:0048286alveolus developmentBiological ProcessISS
GO:0048469cell maturationBiological ProcessISS
GO:0048754branching morphogenesis of a tubeBiological ProcessISS
GO:0050679positive regulation of epithelial cell proliferationBiological ProcessISS
GO:0050769positive regulation of neurogenesisBiological ProcessIEP (15258583)
GO:0045165cell fate commitmentBiological ProcessISS
GO:0043129surfactant homeostasisBiological ProcessISS
GO:0006468protein amino acid phosphorylationBiological ProcessIEA
GO:0008584male gonad developmentBiological ProcessIDA (16672722)
GO:0016477cell migrationBiological ProcessISS
GO:0002053positive regulation of mesenchymal cell proliferationBiological ProcessISS
GO:0001570vasculogenesisBiological ProcessISS
GO:0001541ovarian follicle developmentBiological ProcessISS
GO:0030097hemopoiesisBiological ProcessISS
GO:0030324lung developmentBiological ProcessISS
GO:0042221response to chemical stimulusBiological ProcessIDA (16361360)
GO:0055074calcium ion homeostasisBiological ProcessISS
Other Database Cross Links
NCBI Entrez Gene:25589
RGD:2965
Ensembl:
dbSNP:Kdr