ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

DHX15

Full Name:

DEAH (Asp-Glu-Ala-His) box polypeptide 15

Alias:

DBP1|DDX15|HRH2|PRP43|PRPF43|PrPp43p

Organism:

Homo sapiens (Human)

Chromosome:

4

Genetic Location:

4p15.3

Physical Location:

24138184-24195281 on NC_000004.10, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		AB001636
Fold Change:		0.78
P Value:		0.0053

Dataset Information

Name:		12774316
Method:		Microarray
Tissue:		Temporal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed
Summary:		To identify candidate mechanisms for alcohol abuse, the expression of 12,626 genes was measured in postmortem temporal cortex from 11 subjects with a history of alcohol abuse or dependence, with or without other psychiatric diagnoses and compared pairwise with the expression in 11 nonalcoholic subjects matched for the other psychiatric diagnoses and demographics. Genes were defined to have altered expression in alcohol abuse if: 1) the gene showed decreased expression in at least 10 of 11 subjects with alcohol abuse, or showed increased expression in at least 10 of 11 subjects with this diagnosis compared to matched non-abusers (P<0.007, X2test); or 2) the difference in the mean abuser/non-abuser ratio for the gene from value of 1.0 was significant at P<0.05 (one sample t-test). In subjects with a history of alcohol abuse or dependence, 163 genes were changed significantly.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_001358.2	NP_001349.2	NC_000004.10 range: 24138184..24195281, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005689	U12-dependent spliceosome	Cellular Component	IDA (15146077)
GO:0005634	nucleus	Cellular Component	TAS (9388478)
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0008026	ATP-dependent helicase activity	Molecular Function	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0003724	RNA helicase activity	Molecular Function	TAS (7935475)
GO:0003676	nucleic acid binding	Molecular Function	IEA
GO:0017111	nucleoside-triphosphatase activity	Molecular Function	IEA
GO:0006397	mRNA processing	Biological Process	TAS (7935475)
GO:0008380	RNA splicing	Biological Process	IC (15146077)

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000109606

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: