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Gene Information
Gene ID:8725
Symbol:C19orf2
Full Name:chromosome 19 open reading frame 2
Alias:FLJ10575|NNX3|RMP|URI
Organism:Homo sapiens (Human)
Chromosome:19
Genetic Location:19q12
Physical Location:35125264-35198455 on NC_000019.8
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:AB006572
Fold Change:0.79
P Value:0.0002
Dataset Information
Name:12774316
Method:Microarray
Tissue:Temporal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed
Summary:To identify candidate mechanisms for alcohol abuse, the expression of 12,626 genes was measured in postmortem temporal cortex from 11 subjects with a history of alcohol abuse or dependence, with or without other psychiatric diagnoses and compared pairwise with the expression in 11 nonalcoholic subjects matched for the other psychiatric diagnoses and demographics. Genes were defined to have altered expression in alcohol abuse if: 1) the gene showed decreased expression in at least 10 of 11 subjects with alcohol abuse, or showed increased expression in at least 10 of 11 subjects with this diagnosis compared to matched non-abusers (P<0.007, X2test); or 2) the difference in the mean abuser/non-abuser ratio for the gene from value of 1.0 was significant at P<0.05 (one sample t-test). In subjects with a history of alcohol abuse or dependence, 163 genes were changed significantly.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_003796.2NP_003787.2NC_000019.8 range: 35125264..35198455
NM_134447.1NP_604431.1NC_000019.8 range: 35125264..35198455
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentTAS (9878255)
GO:0005665DNA-directed RNA polymerase II, core complexCellular ComponentIDA (9819440)
GO:0005737cytoplasmCellular ComponentTAS (9878255)
GO:0016272prefoldin complexCellular ComponentIEA
GO:0003714transcription corepressor activityMolecular FunctionIMP (9819440)
GO:0051082unfolded protein bindingMolecular FunctionIEA
GO:0006357regulation of transcription from RNA polymerase II promoterBiological ProcessIMP (9819440)
GO:0006457protein foldingBiological ProcessIEA
GO:0009615response to virusBiological ProcessIMP (9819440)
Other Database Cross Links
NCBI Entrez Gene:8725
HGNC:13236
Ensembl:ENSG00000105176
MIM:603494
HPRD:11943
HuGE Navigator:8725
dbSNP:C19orf2
GeneCard:C19orf2
AceView:C19orf2