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Gene Information
Gene ID:8943
Full Name:adaptor-related protein complex 3, delta 1 subunit
Organism:Homo sapiens (Human)
Genetic Location:19p13.3
Physical Location:2051992-2102555 on NC_000019.8, complement
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:AF002163
Fold Change:0.75
P Value:0.0004
Dataset Information
Tissue:Temporal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed
Summary:To identify candidate mechanisms for alcohol abuse, the expression of 12,626 genes was measured in postmortem temporal cortex from 11 subjects with a history of alcohol abuse or dependence, with or without other psychiatric diagnoses and compared pairwise with the expression in 11 nonalcoholic subjects matched for the other psychiatric diagnoses and demographics. Genes were defined to have altered expression in alcohol abuse if: 1) the gene showed decreased expression in at least 10 of 11 subjects with alcohol abuse, or showed increased expression in at least 10 of 11 subjects with this diagnosis compared to matched non-abusers (P<0.007, X2test); or 2) the difference in the mean abuser/non-abuser ratio for the gene from value of 1.0 was significant at P<0.05 (one sample t-test). In subjects with a history of alcohol abuse or dependence, 163 genes were changed significantly.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_001077523.1NP_001070991.1NC_000019.8 range: 2051992..2102555, complement
NM_003938.5NP_003929.4NC_000019.8 range: 2051992..2102555, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0000139Golgi membraneCellular ComponentIEA
GO:0005794Golgi apparatusCellular ComponentTAS (9151686)
GO:0016020membraneCellular ComponentIEA
GO:0030117membrane coatCellular ComponentIEA
GO:0005215transporter activityMolecular FunctionTAS (9303295)
GO:0005515protein bindingMolecular FunctionIEA
GO:0006726eye pigment biosynthetic processBiological ProcessTAS (9303295)
GO:0006886intracellular protein transportBiological ProcessTAS (9151686)
GO:0016192vesicle-mediated transportBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:8943
HuGE Navigator:8943