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Gene Information
Gene ID:25820
Symbol:ARIH1
Full Name:ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein, 1 (Drosophila)
Alias:ARI|DKFZp686O13120|FLJ20329|FLJ93118|HARI|HHARI|UBCH7BP
Organism:Homo sapiens (Human)
Chromosome:15
Genetic Location:15q24
Physical Location:70553720-70662876 on NC_000015.8
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:AJ009771
Fold Change:0.6
P Value:0.00029
Dataset Information
Name:12774316
Method:Microarray
Tissue:Temporal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed
Summary:To identify candidate mechanisms for alcohol abuse, the expression of 12,626 genes was measured in postmortem temporal cortex from 11 subjects with a history of alcohol abuse or dependence, with or without other psychiatric diagnoses and compared pairwise with the expression in 11 nonalcoholic subjects matched for the other psychiatric diagnoses and demographics. Genes were defined to have altered expression in alcohol abuse if: 1) the gene showed decreased expression in at least 10 of 11 subjects with alcohol abuse, or showed increased expression in at least 10 of 11 subjects with this diagnosis compared to matched non-abusers (P<0.007, X2test); or 2) the difference in the mean abuser/non-abuser ratio for the gene from value of 1.0 was significant at P<0.05 (one sample t-test). In subjects with a history of alcohol abuse or dependence, 163 genes were changed significantly.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_005744.3NP_005735.2NC_000015.8 range: 70553720..70662876
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0000151ubiquitin ligase complexCellular ComponentTAS (10521492)
GO:0005737cytoplasmCellular ComponentIEA
GO:0005515protein bindingMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionIPI (10521492)
GO:0008270zinc ion bindingMolecular FunctionIEA
GO:0019787small conjugating protein ligase activityMolecular FunctionTAS (10521492)
GO:0046872metal ion bindingMolecular FunctionIEA
GO:0006511ubiquitin-dependent protein catabolic processBiological ProcessTAS (10521492)
GO:0006512ubiquitin cycleBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:25820
HGNC:689
Ensembl:ENSG00000166233
MIM:605624
HPRD:05730
HuGE Navigator:25820
dbSNP:ARIH1
GeneCard:ARIH1
AceView:ARIH1