ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

MYC

Full Name:

v-myc myelocytomatosis viral oncogene homolog (avian)

Alias:

c-Myc

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

8q24.21

Physical Location:

128817497-128822855 on NC_000008.9

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 17869 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		12774316
Method:		Microarray
Tissue:		Temporal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed
Summary:		To identify candidate mechanisms for alcohol abuse, the expression of 12,626 genes was measured in postmortem temporal cortex from 11 subjects with a history of alcohol abuse or dependence, with or without other psychiatric diagnoses and compared pairwise with the expression in 11 nonalcoholic subjects matched for the other psychiatric diagnoses and demographics. Genes were defined to have altered expression in alcohol abuse if: 1) the gene showed decreased expression in at least 10 of 11 subjects with alcohol abuse, or showed increased expression in at least 10 of 11 subjects with this diagnosis compared to matched non-abusers (P<0.007, X2test); or 2) the difference in the mean abuser/non-abuser ratio for the gene from value of 1.0 was significant at P<0.05 (one sample t-test). In subjects with a history of alcohol abuse or dependence, 163 genes were changed significantly.

Gene Information

Original ID1:

MYC

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_002467.3	NP_002458.2	NC_000008.9 range: 128817497..128822855

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	NAS (2834731)
GO:0005634	nucleus	Cellular Component	IEA
GO:0005634	nucleus	Cellular Component	IDA (15994933)
GO:0003677	DNA binding	Molecular Function	NAS (2834731)
GO:0005515	protein binding	Molecular Function	IPI (9308237\|9708738\|10597290\|12706874)
GO:0003700	transcription factor activity	Molecular Function	TAS (9924025)
GO:0003700	transcription factor activity	Molecular Function	IEA
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IEA
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	NAS (2834731)
GO:0006357	regulation of transcription from RNA polymerase II promoter	Biological Process	TAS (9924025)
GO:0006879	cellular iron ion homeostasis	Biological Process	TAS (9924025)
GO:0007050	cell cycle arrest	Biological Process	TAS (10962037)
GO:0008284	positive regulation of cell proliferation	Biological Process	IDA (15994933)