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Gene Information
Gene ID:1466
Symbol:CSRP2
Full Name:cysteine and glycine-rich protein 2
Alias:CRP2|LMO5|SmLIM
Organism:Homo sapiens (Human)
Chromosome:12
Genetic Location:12q21.1
Physical Location:75776626-75796929 on NC_000012.10, complement
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:U57646
Fold Change:0.74
P Value:0.012
Dataset Information
Name:12774316
Method:Microarray
Tissue:Temporal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed
Summary:To identify candidate mechanisms for alcohol abuse, the expression of 12,626 genes was measured in postmortem temporal cortex from 11 subjects with a history of alcohol abuse or dependence, with or without other psychiatric diagnoses and compared pairwise with the expression in 11 nonalcoholic subjects matched for the other psychiatric diagnoses and demographics. Genes were defined to have altered expression in alcohol abuse if: 1) the gene showed decreased expression in at least 10 of 11 subjects with alcohol abuse, or showed increased expression in at least 10 of 11 subjects with this diagnosis compared to matched non-abusers (P<0.007, X2test); or 2) the difference in the mean abuser/non-abuser ratio for the gene from value of 1.0 was significant at P<0.05 (one sample t-test). In subjects with a history of alcohol abuse or dependence, 163 genes were changed significantly.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_001321.1NP_001312.1NC_000012.10 range: 75776626..75796929, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentNAS
GO:0003674molecular_functionMolecular FunctionND
GO:0046872metal ion bindingMolecular FunctionIEA
GO:0008270zinc ion bindingMolecular FunctionIEA
GO:0007517muscle developmentBiological ProcessNAS
GO:0007275multicellular organismal developmentBiological ProcessIEA
GO:0009887organ morphogenesisBiological ProcessNAS
GO:0016049cell growthBiological ProcessNAS
GO:0030154cell differentiationBiological ProcessNAS
GO:0008283cell proliferationBiological ProcessNAS
Other Database Cross Links
NCBI Entrez Gene:1466
HGNC:2470
Ensembl:ENSG00000175183
MIM:601871
HPRD:03523
HuGE Navigator:1466
dbSNP:CSRP2
GeneCard:CSRP2
AceView:CSRP2