ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

CELSR1

Full Name:

cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)

Alias:

CDHF9|DKFZp434P0729|FMI2|HFMI2|ME2

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

22q13.3

Physical Location:

45135394-45311730 on NC_000022.9, complement

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 12614 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		12774316
Method:		Microarray
Tissue:		Temporal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed
Summary:		To identify candidate mechanisms for alcohol abuse, the expression of 12,626 genes was measured in postmortem temporal cortex from 11 subjects with a history of alcohol abuse or dependence, with or without other psychiatric diagnoses and compared pairwise with the expression in 11 nonalcoholic subjects matched for the other psychiatric diagnoses and demographics. Genes were defined to have altered expression in alcohol abuse if: 1) the gene showed decreased expression in at least 10 of 11 subjects with alcohol abuse, or showed increased expression in at least 10 of 11 subjects with this diagnosis compared to matched non-abusers (P<0.007, X2test); or 2) the difference in the mean abuser/non-abuser ratio for the gene from value of 1.0 was significant at P<0.05 (one sample t-test). In subjects with a history of alcohol abuse or dependence, 163 genes were changed significantly.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_014246.1	NP_055061.1	NC_000022.9 range: 45135394..45311730, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005886	plasma membrane	Cellular Component	IEA
GO:0005887	integral to plasma membrane	Cellular Component	TAS (9339365)
GO:0046983	protein dimerization activity	Molecular Function	NAS (9339365)
GO:0004930	G-protein coupled receptor activity	Molecular Function	NAS (9339365)
GO:0005509	calcium ion binding	Molecular Function	IEA
GO:0007417	central nervous system development	Biological Process	TAS (10716726)
GO:0007417	central nervous system development	Biological Process	NAS (9339365)
GO:0007275	multicellular organismal development	Biological Process	IEA
GO:0007218	neuropeptide signaling pathway	Biological Process	IEA
GO:0007165	signal transduction	Biological Process	IEA
GO:0007156	homophilic cell adhesion	Biological Process	IEA
GO:0001843	neural tube closure	Biological Process	ISS
GO:0001736	establishment of planar polarity	Biological Process	ISS