ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

12614

Symbol:

Celsr1

Full Name:

cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)

Alias:

Crsh|Scy

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

15 E2|15 49.0 cM

Physical Location:

85729187-85864206 on NC_000081.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 9620 Symbol (Name): CELSR1 (cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila))

Ortholog Status:

The human GeneID 9620 is also in human dataset(s).

Gene in Ethanol Study Datasets

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Lore5	Alcohol-induced Loss of Righting Reflex	15		18.8-61.7 (cM)	4		Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_009886.2	NP_034016.2	NC_000081.5 range: 85729187..85864206, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005887	integral to plasma membrane	Cellular Component	TAS (9339365)
GO:0016020	membrane	Cellular Component	IEA
GO:0016021	integral to membrane	Cellular Component	RCA (12466851)
GO:0005615	extracellular space	Cellular Component	RCA (12466851)
GO:0046983	protein dimerization activity	Molecular Function	NAS (9339365)
GO:0005509	calcium ion binding	Molecular Function	TAS (12842012)
GO:0004930	G-protein coupled receptor activity	Molecular Function	NAS (9339365)
GO:0004872	receptor activity	Molecular Function	IEA
GO:0004871	signal transducer activity	Molecular Function	IEA
GO:0045176	apical protein localization	Biological Process	IMP (16687519)
GO:0042472	inner ear morphogenesis	Biological Process	IMP (12842012)
GO:0042249	establishment of polarity of embryonic epithelium	Biological Process	IMP (12842012)
GO:0046928	regulation of neurotransmitter secretion	Biological Process	NAS (9339365)
GO:0007626	locomotory behavior	Biological Process	IMP (10932191)
GO:0007417	central nervous system development	Biological Process	NAS (9339365)
GO:0007275	multicellular organismal development	Biological Process	IEA
GO:0007267	cell-cell signaling	Biological Process	NAS (9339365)
GO:0007218	neuropeptide signaling pathway	Biological Process	IEA
GO:0007186	G-protein coupled receptor protein signaling pathway	Biological Process	IEA
GO:0007165	signal transduction	Biological Process	NAS (9339365)
GO:0007156	homophilic cell adhesion	Biological Process	IEA
GO:0001843	neural tube closure	Biological Process	IMP (12842012)
GO:0001702	gastrulation with mouth forming second	Biological Process	NAS (9339365)