ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

GGA3

Full Name:

golgi associated, gamma adaptin ear containing, ARF binding protein 3

Alias:

KIAA0154

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

17q25.1

Physical Location:

70744289-70769271 on NC_000017.9, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		12774316
Method:		Microarray
Tissue:		Temporal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed
Summary:		To identify candidate mechanisms for alcohol abuse, the expression of 12,626 genes was measured in postmortem temporal cortex from 11 subjects with a history of alcohol abuse or dependence, with or without other psychiatric diagnoses and compared pairwise with the expression in 11 nonalcoholic subjects matched for the other psychiatric diagnoses and demographics. Genes were defined to have altered expression in alcohol abuse if: 1) the gene showed decreased expression in at least 10 of 11 subjects with alcohol abuse, or showed increased expression in at least 10 of 11 subjects with this diagnosis compared to matched non-abusers (P<0.007, X2test); or 2) the difference in the mean abuser/non-abuser ratio for the gene from value of 1.0 was significant at P<0.05 (one sample t-test). In subjects with a history of alcohol abuse or dependence, 163 genes were changed significantly.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0010008	endosome membrane	Cellular Component	IEA
GO:0005622	intracellular	Cellular Component	IEA
GO:0005768	endosome	Cellular Component	IEA
GO:0005794	Golgi apparatus	Cellular Component	IEA
GO:0005802	trans-Golgi network	Cellular Component	IDA (10749927)
GO:0030131	clathrin adaptor complex	Cellular Component	IEA
GO:0030117	membrane coat	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0005515	protein binding	Molecular Function	IPI (12505986)
GO:0030306	ADP-ribosylation factor binding	Molecular Function	IDA (10749927)
GO:0016192	vesicle-mediated transport	Biological Process	IEA
GO:0006886	intracellular protein transport	Biological Process	NAS (10749927)