ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

OPA1

Full Name:

optic atrophy 1 (autosomal dominant)

Alias:

FLJ12460|KIAA0567|MGM1|NPG|NTG|largeG

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

3q28-q29|3q28-q29

Physical Location:

194793805-194898008 on NC_000003.10

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		12774316
Method:		Microarray
Tissue:		Temporal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed
Summary:		To identify candidate mechanisms for alcohol abuse, the expression of 12,626 genes was measured in postmortem temporal cortex from 11 subjects with a history of alcohol abuse or dependence, with or without other psychiatric diagnoses and compared pairwise with the expression in 11 nonalcoholic subjects matched for the other psychiatric diagnoses and demographics. Genes were defined to have altered expression in alcohol abuse if: 1) the gene showed decreased expression in at least 10 of 11 subjects with alcohol abuse, or showed increased expression in at least 10 of 11 subjects with this diagnosis compared to matched non-abusers (P<0.007, X2test); or 2) the difference in the mean abuser/non-abuser ratio for the gene from value of 1.0 was significant at P<0.05 (one sample t-test). In subjects with a history of alcohol abuse or dependence, 163 genes were changed significantly.

Gene Information

Original ID1:

OPA1

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016020	membrane	Cellular Component	IEA
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0030061	mitochondrial crista	Cellular Component	IDA (12504110)
GO:0030425	dendrite	Cellular Component	ISS (11847212)
GO:0005758	mitochondrial intermembrane space	Cellular Component	ISS (11847212)
GO:0005741	mitochondrial outer membrane	Cellular Component	IDA (12504110)
GO:0005739	mitochondrion	Cellular Component	IEA
GO:0005525	GTP binding	Molecular Function	IEA
GO:0003924	GTPase activity	Molecular Function	TAS (11017080)
GO:0000287	magnesium ion binding	Molecular Function	NAS (11017080)
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0019896	axon transport of mitochondrion	Biological Process	TAS (11017080)
GO:0045768	positive regulation of anti-apoptosis	Biological Process	IDA (12509422)
GO:0008053	mitochondrial fusion	Biological Process	TAS (12509422)
GO:0007605	sensory perception of sound	Biological Process	IEA
GO:0007601	visual perception	Biological Process	IMP (11017080)
GO:0007007	inner mitochondrial membrane organization and biogenesis	Biological Process	IDA (12509422)
GO:0006915	apoptosis	Biological Process	IEA
GO:0000266	mitochondrial fission	Biological Process	TAS (12509422)
GO:0050896	response to stimulus	Biological Process	IEA