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Gene Information
Gene ID:1339
Symbol:COX6A2
Full Name:cytochrome c oxidase subunit VIa polypeptide 2
Alias:COX6AH|COXVIAH
Organism:Homo sapiens (Human)
Chromosome:16
Genetic Location:16p
Physical Location:31346555-31347221 on NC_000016.8, complement
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:F27891
Fold Change:1.32
P Value:0.018
Dataset Information
Name:12774316
Method:Microarray
Tissue:Temporal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed
Summary:To identify candidate mechanisms for alcohol abuse, the expression of 12,626 genes was measured in postmortem temporal cortex from 11 subjects with a history of alcohol abuse or dependence, with or without other psychiatric diagnoses and compared pairwise with the expression in 11 nonalcoholic subjects matched for the other psychiatric diagnoses and demographics. Genes were defined to have altered expression in alcohol abuse if: 1) the gene showed decreased expression in at least 10 of 11 subjects with alcohol abuse, or showed increased expression in at least 10 of 11 subjects with this diagnosis compared to matched non-abusers (P<0.007, X2test); or 2) the difference in the mean abuser/non-abuser ratio for the gene from value of 1.0 was significant at P<0.05 (one sample t-test). In subjects with a history of alcohol abuse or dependence, 163 genes were changed significantly.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_005205.2NP_005196.1NC_000016.8 range: 31346555..31347221, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005739mitochondrionCellular ComponentIEA
GO:0005740mitochondrial envelopeCellular ComponentIEA
GO:0005743mitochondrial inner membraneCellular ComponentIEA
GO:0016020membraneCellular ComponentIEA
GO:0004129cytochrome-c oxidase activityMolecular FunctionIEA
GO:0009055electron carrier activityMolecular FunctionIEA
GO:0006091generation of precursor metabolites and energyBiological ProcessTAS (9284905)
Other Database Cross Links
NCBI Entrez Gene:1339
HGNC:2279
Ensembl:ENSG00000156885
MIM:602009
HPRD:03598
HuGE Navigator:1339
dbSNP:COX6A2
GeneCard:COX6A2
AceView:COX6A2