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Gene Information
Gene ID:27089
Symbol:UQCRQ
Full Name:ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa
Alias:QCR8|QP-C
Organism:Homo sapiens (Human)
Chromosome:5
Genetic Location:5q31.1
Physical Location:132230217-132232434 on NC_000005.8
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:AI540957
Fold Change:0.86
P Value:0.014
Dataset Information
Name:12774316
Method:Microarray
Tissue:Temporal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed
Summary:To identify candidate mechanisms for alcohol abuse, the expression of 12,626 genes was measured in postmortem temporal cortex from 11 subjects with a history of alcohol abuse or dependence, with or without other psychiatric diagnoses and compared pairwise with the expression in 11 nonalcoholic subjects matched for the other psychiatric diagnoses and demographics. Genes were defined to have altered expression in alcohol abuse if: 1) the gene showed decreased expression in at least 10 of 11 subjects with alcohol abuse, or showed increased expression in at least 10 of 11 subjects with this diagnosis compared to matched non-abusers (P<0.007, X2test); or 2) the difference in the mean abuser/non-abuser ratio for the gene from value of 1.0 was significant at P<0.05 (one sample t-test). In subjects with a history of alcohol abuse or dependence, 163 genes were changed significantly.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_014402.4NP_055217.2NC_000005.8 range: 132230217..132232434
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005739mitochondrionCellular ComponentIEA
GO:0005746mitochondrial respiratory chainCellular ComponentIEA
GO:0016020membraneCellular ComponentIEA
GO:0008121ubiquinol-cytochrome-c reductase activityMolecular FunctionIEA
GO:0006810transportBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:27089
HGNC:29594
Ensembl:ENSG00000164405
MIM:612080
HPRD:17941
HuGE Navigator:27089
dbSNP:UQCRQ
GeneCard:UQCRQ
AceView:UQCRQ