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Gene Information
Gene ID:9884
Symbol:LRRC37A
Full Name:leucine rich repeat containing 37A
Alias:DKFZp686N1231|KIAA0563
Organism:Homo sapiens (Human)
Chromosome:17
Genetic Location:17q21.31
Physical Location:41728273-41770917 on NC_000017.9
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:H16917
Fold Change:2.17
P Value:0.0005
Dataset Information
Name:12774316
Method:Microarray
Tissue:Temporal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed
Summary:To identify candidate mechanisms for alcohol abuse, the expression of 12,626 genes was measured in postmortem temporal cortex from 11 subjects with a history of alcohol abuse or dependence, with or without other psychiatric diagnoses and compared pairwise with the expression in 11 nonalcoholic subjects matched for the other psychiatric diagnoses and demographics. Genes were defined to have altered expression in alcohol abuse if: 1) the gene showed decreased expression in at least 10 of 11 subjects with alcohol abuse, or showed increased expression in at least 10 of 11 subjects with this diagnosis compared to matched non-abusers (P<0.007, X2test); or 2) the difference in the mean abuser/non-abuser ratio for the gene from value of 1.0 was significant at P<0.05 (one sample t-test). In subjects with a history of alcohol abuse or dependence, 163 genes were changed significantly.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_014834.3NP_055649.3NC_000017.9 range: 41728273..41770917
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005515protein bindingMolecular FunctionIEA
Other Database Cross Links
NCBI Entrez Gene:9884
HGNC:29069
Ensembl:ENSG00000176681
MIM:
HPRD:14303
HuGE Navigator:9884
dbSNP:LRRC37A
GeneCard:LRRC37A
AceView:LRRC37A