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Gene Information
Gene ID:1933
Symbol:EEF1B2
Full Name:eukaryotic translation elongation factor 1 beta 2
Alias:EEF1B|EEF1B1|EF1B
Organism:Homo sapiens (Human)
Chromosome:2
Genetic Location:2q33-q34
Physical Location:206732562-206735897 on NC_000002.10
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:X60489
Fold Change:0.65
P Value:0.0075
Dataset Information
Name:12774316
Method:Microarray
Tissue:Temporal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed
Summary:To identify candidate mechanisms for alcohol abuse, the expression of 12,626 genes was measured in postmortem temporal cortex from 11 subjects with a history of alcohol abuse or dependence, with or without other psychiatric diagnoses and compared pairwise with the expression in 11 nonalcoholic subjects matched for the other psychiatric diagnoses and demographics. Genes were defined to have altered expression in alcohol abuse if: 1) the gene showed decreased expression in at least 10 of 11 subjects with alcohol abuse, or showed increased expression in at least 10 of 11 subjects with this diagnosis compared to matched non-abusers (P<0.007, X2test); or 2) the difference in the mean abuser/non-abuser ratio for the gene from value of 1.0 was significant at P<0.05 (one sample t-test). In subjects with a history of alcohol abuse or dependence, 163 genes were changed significantly.
Linkage Dataset
MarkerLODP valueLocation (bp)
D2S117  195326948
Region:195326948-216757195
Phenotype:Alcoholism phenotype along with age, gender, and P300 or constraint
Name:15211641
Method:Linkage
Publication:Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_001037663.1NP_001032752.1NC_000002.10 range: 206732562..206735897
NM_001959.3NP_001950.1NC_000002.10 range: 206732562..206735897
NM_021121.3NP_066944.1NC_000002.10 range: 206732562..206735897
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005829cytosolCellular ComponentEXP (10368288)
GO:0005853eukaryotic translation elongation factor 1 complexCellular ComponentNAS (1886777)
GO:0003746translation elongation factor activityMolecular FunctionNAS (1886777)
GO:0005515protein bindingMolecular FunctionIPI (16169070|17353931)
GO:0006414translational elongationBiological ProcessEXP (15189156)
GO:0006414translational elongationBiological ProcessNAS (1886777)
Other Database Cross Links
NCBI Entrez Gene:1933
HGNC:3208
Ensembl:ENSG00000114942
MIM:600655
HPRD:02804
HuGE Navigator:1933
dbSNP:EEF1B2
GeneCard:EEF1B2
AceView:EEF1B2