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Gene Information
Gene ID:10965
Symbol:ACOT2
Full Name:acyl-CoA thioesterase 2
Alias:Mte1|PTE2|ZAP128
Organism:Homo sapiens (Human)
Chromosome:14
Genetic Location:14q24.3
Physical Location:73105524-73112111 on NC_000014.7
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:L40401
Fold Change:1.31
P Value:0.01
Dataset Information
Name:12774316
Method:Microarray
Tissue:Temporal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed
Summary:To identify candidate mechanisms for alcohol abuse, the expression of 12,626 genes was measured in postmortem temporal cortex from 11 subjects with a history of alcohol abuse or dependence, with or without other psychiatric diagnoses and compared pairwise with the expression in 11 nonalcoholic subjects matched for the other psychiatric diagnoses and demographics. Genes were defined to have altered expression in alcohol abuse if: 1) the gene showed decreased expression in at least 10 of 11 subjects with alcohol abuse, or showed increased expression in at least 10 of 11 subjects with this diagnosis compared to matched non-abusers (P<0.007, X2test); or 2) the difference in the mean abuser/non-abuser ratio for the gene from value of 1.0 was significant at P<0.05 (one sample t-test). In subjects with a history of alcohol abuse or dependence, 163 genes were changed significantly.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_006821.4NP_006812.3NC_000014.7 range: 73105524..73112111
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005739mitochondrionCellular ComponentIDA (16940157)
GO:0004091carboxylesterase activityMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionIPI (17353931)
GO:0016290palmitoyl-CoA hydrolase activityMolecular FunctionIEA
GO:0016787hydrolase activityMolecular FunctionIEA
GO:0000038very-long-chain fatty acid metabolic processBiological ProcessIDA (16940157)
GO:0001676long-chain fatty acid metabolic processBiological ProcessIDA (16940157)
GO:0006629lipid metabolic processBiological ProcessIEA
GO:0006637acyl-CoA metabolic processBiological ProcessIDA (10944470|16940157)
Other Database Cross Links
NCBI Entrez Gene:10965
HGNC:18431
Ensembl:ENSG00000119673
MIM:609972
HPRD:10173
HuGE Navigator:10965
dbSNP:ACOT2
GeneCard:ACOT2
AceView:ACOT2