ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

ACOT2

Full Name:

acyl-CoA thioesterase 2

Alias:

Mte1|PTE2|ZAP128

Organism:

Homo sapiens (Human)

Chromosome:

14

Genetic Location:

14q24.3

Physical Location:

73105524-73112111 on NC_000014.7

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		L40401
Fold Change:		1.31
P Value:		0.01

Dataset Information

Name:		12774316
Method:		Microarray
Tissue:		Temporal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed
Summary:		To identify candidate mechanisms for alcohol abuse, the expression of 12,626 genes was measured in postmortem temporal cortex from 11 subjects with a history of alcohol abuse or dependence, with or without other psychiatric diagnoses and compared pairwise with the expression in 11 nonalcoholic subjects matched for the other psychiatric diagnoses and demographics. Genes were defined to have altered expression in alcohol abuse if: 1) the gene showed decreased expression in at least 10 of 11 subjects with alcohol abuse, or showed increased expression in at least 10 of 11 subjects with this diagnosis compared to matched non-abusers (P<0.007, X2test); or 2) the difference in the mean abuser/non-abuser ratio for the gene from value of 1.0 was significant at P<0.05 (one sample t-test). In subjects with a history of alcohol abuse or dependence, 163 genes were changed significantly.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_006821.4	NP_006812.3	NC_000014.7 range: 73105524..73112111

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005739	mitochondrion	Cellular Component	IDA (16940157)
GO:0004091	carboxylesterase activity	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (17353931)
GO:0016290	palmitoyl-CoA hydrolase activity	Molecular Function	IEA
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0000038	very-long-chain fatty acid metabolic process	Biological Process	IDA (16940157)
GO:0001676	long-chain fatty acid metabolic process	Biological Process	IDA (16940157)
GO:0006629	lipid metabolic process	Biological Process	IEA
GO:0006637	acyl-CoA metabolic process	Biological Process	IDA (10944470\|16940157)

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000119673

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: