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Gene Information
Gene ID:10277
Symbol:UBE4B
Full Name:ubiquitination factor E4B (UFD2 homolog, yeast)
Alias:E4|HDNB1|KIAA0684|UBOX3|UFD2
Organism:Homo sapiens (Human)
Chromosome:1
Genetic Location:1p36.3
Physical Location:10015602-10163883 on NC_000001.9
Gene Type:protein-coding
Orthologs:This gene has Mouse: 63958 ortholog(s) in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:AB014584
Fold Change:1.94
P Value:0.0169
Dataset Information
Name:12774316
Method:Microarray
Tissue:Temporal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed
Summary:To identify candidate mechanisms for alcohol abuse, the expression of 12,626 genes was measured in postmortem temporal cortex from 11 subjects with a history of alcohol abuse or dependence, with or without other psychiatric diagnoses and compared pairwise with the expression in 11 nonalcoholic subjects matched for the other psychiatric diagnoses and demographics. Genes were defined to have altered expression in alcohol abuse if: 1) the gene showed decreased expression in at least 10 of 11 subjects with alcohol abuse, or showed increased expression in at least 10 of 11 subjects with this diagnosis compared to matched non-abusers (P<0.007, X2test); or 2) the difference in the mean abuser/non-abuser ratio for the gene from value of 1.0 was significant at P<0.05 (one sample t-test). In subjects with a history of alcohol abuse or dependence, 163 genes were changed significantly.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_001105562.1NP_001099032.1NC_000001.9 range: 10015602..10163883
NM_006048.3NP_006039.2NC_000001.9 range: 10015602..10163883
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0000151ubiquitin ligase complexCellular ComponentTAS (11802788)
GO:0005737cytoplasmCellular ComponentISS
GO:0004842ubiquitin-protein ligase activityMolecular FunctionIEA
GO:0019899enzyme bindingMolecular FunctionISS
GO:0006915apoptosisBiological ProcessIDA (11802788)
GO:0009411response to UVBiological ProcessIDA (11802788)
GO:0042787protein ubiquitination during ubiquitin-dependent protein catabolic processBiological ProcessTAS (11802788)
Other Database Cross Links
NCBI Entrez Gene:10277
HGNC:12500
Ensembl:ENSG00000130939
MIM:
HPRD:11659
HuGE Navigator:10277
dbSNP:UBE4B
GeneCard:UBE4B
AceView:UBE4B