ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

CDK2AP1

Full Name:

CDK2-associated protein 1

Alias:

DOC1|DORC1|ST19|doc-1|p12DOC-1

Organism:

Homo sapiens (Human)

Chromosome:

12

Genetic Location:

12q24.31

Physical Location:

122311490-122322639 on NC_000012.10, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		AF006484
Fold Change:		0.85
P Value:		0.032

Dataset Information

Name:		12774316
Method:		Microarray
Tissue:		Temporal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed
Summary:		To identify candidate mechanisms for alcohol abuse, the expression of 12,626 genes was measured in postmortem temporal cortex from 11 subjects with a history of alcohol abuse or dependence, with or without other psychiatric diagnoses and compared pairwise with the expression in 11 nonalcoholic subjects matched for the other psychiatric diagnoses and demographics. Genes were defined to have altered expression in alcohol abuse if: 1) the gene showed decreased expression in at least 10 of 11 subjects with alcohol abuse, or showed increased expression in at least 10 of 11 subjects with this diagnosis compared to matched non-abusers (P<0.007, X2test); or 2) the difference in the mean abuser/non-abuser ratio for the gene from value of 1.0 was significant at P<0.05 (one sample t-test). In subjects with a history of alcohol abuse or dependence, 163 genes were changed significantly.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_004642.2	NP_004633.1	NC_000012.10 range: 122311490..122322639, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	TAS (9506968)
GO:0005737	cytoplasm	Cellular Component	TAS (9506968)
GO:0003677	DNA binding	Molecular Function	TAS (9506968)
GO:0004871	signal transducer activity	Molecular Function	NR
GO:0005515	protein binding	Molecular Function	IPI (17353931)
GO:0000084	S phase of mitotic cell cycle	Biological Process	TAS (9506968)
GO:0006261	DNA-dependent DNA replication	Biological Process	TAS (9506968)
GO:0006468	protein amino acid phosphorylation	Biological Process	TAS (9506968)
GO:0045786	negative regulation of cell cycle	Biological Process	IEA

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000111328

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: