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Gene Information
Gene ID:9716
Symbol:AQR
Full Name:aquarius homolog (mouse)
Alias:DKFZp686B23123|IBP160|KIAA0560
Organism:Homo sapiens (Human)
Chromosome:15
Genetic Location:15q14
Physical Location:32935843-33049286 on NC_000015.8, complement
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:AB011132
Fold Change:0.8
P Value:0.0003
Dataset Information
Name:12774316
Method:Microarray
Tissue:Temporal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed
Summary:To identify candidate mechanisms for alcohol abuse, the expression of 12,626 genes was measured in postmortem temporal cortex from 11 subjects with a history of alcohol abuse or dependence, with or without other psychiatric diagnoses and compared pairwise with the expression in 11 nonalcoholic subjects matched for the other psychiatric diagnoses and demographics. Genes were defined to have altered expression in alcohol abuse if: 1) the gene showed decreased expression in at least 10 of 11 subjects with alcohol abuse, or showed increased expression in at least 10 of 11 subjects with this diagnosis compared to matched non-abusers (P<0.007, X2test); or 2) the difference in the mean abuser/non-abuser ratio for the gene from value of 1.0 was significant at P<0.05 (one sample t-test). In subjects with a history of alcohol abuse or dependence, 163 genes were changed significantly.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_014691.2NP_055506.1NC_000015.8 range: 32935843..33049286, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentIEA
GO:0005681spliceosomeCellular ComponentIEA
GO:0003723RNA bindingMolecular FunctionIEA
GO:0006397mRNA processingBiological ProcessIEA
GO:0008380RNA splicingBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:9716
HGNC:29513
Ensembl:ENSG00000021776
MIM:610548
HPRD:12468
HuGE Navigator:9716
dbSNP:AQR
GeneCard:AQR
AceView:AQR