ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

DAG1

Full Name:

dystroglycan 1 (dystrophin-associated glycoprotein 1)

Alias:

156DAG|A3a|AGRNR|DAG

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

3p21

Physical Location:

49482568-49548051 on NC_000003.10

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 13138 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		12774316
Method:		Microarray
Tissue:		Temporal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed
Summary:		To identify candidate mechanisms for alcohol abuse, the expression of 12,626 genes was measured in postmortem temporal cortex from 11 subjects with a history of alcohol abuse or dependence, with or without other psychiatric diagnoses and compared pairwise with the expression in 11 nonalcoholic subjects matched for the other psychiatric diagnoses and demographics. Genes were defined to have altered expression in alcohol abuse if: 1) the gene showed decreased expression in at least 10 of 11 subjects with alcohol abuse, or showed increased expression in at least 10 of 11 subjects with this diagnosis compared to matched non-abusers (P<0.007, X2test); or 2) the difference in the mean abuser/non-abuser ratio for the gene from value of 1.0 was significant at P<0.05 (one sample t-test). In subjects with a history of alcohol abuse or dependence, 163 genes were changed significantly.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_004393.2	NP_004384.2	NC_000003.10 range: 49482568..49548051

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0015629	actin cytoskeleton	Cellular Component	TAS (1741056)
GO:0005887	integral to plasma membrane	Cellular Component	TAS (8798547)
GO:0005886	plasma membrane	Cellular Component	NAS (1406935)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005624	membrane fraction	Cellular Component	TAS (8798547)
GO:0005578	proteinaceous extracellular matrix	Cellular Component	TAS (1741056)
GO:0005576	extracellular region	Cellular Component	IEA
GO:0005515	protein binding	Molecular Function	IPI (9417121)
GO:0005509	calcium ion binding	Molecular Function	IEA
GO:0005055	laminin receptor activity	Molecular Function	NR
GO:0006461	protein complex assembly	Biological Process	TAS (1741056)
GO:0006936	muscle contraction	Biological Process	TAS (1406935)