ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

BCS1L

Full Name:

BCS1-like (yeast)

Alias:

BCS|BCS1|BJS|FLNMS|GRACILE|Hs.6719|PTD|h-BCS

Organism:

Homo sapiens (Human)

Chromosome:

2

Genetic Location:

2q33

Physical Location:

219232622-219236409 on NC_000002.10

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		AF038195
Fold Change:		0.72
P Value:		0.013

Dataset Information

Name:		12774316
Method:		Microarray
Tissue:		Temporal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed
Summary:		To identify candidate mechanisms for alcohol abuse, the expression of 12,626 genes was measured in postmortem temporal cortex from 11 subjects with a history of alcohol abuse or dependence, with or without other psychiatric diagnoses and compared pairwise with the expression in 11 nonalcoholic subjects matched for the other psychiatric diagnoses and demographics. Genes were defined to have altered expression in alcohol abuse if: 1) the gene showed decreased expression in at least 10 of 11 subjects with alcohol abuse, or showed increased expression in at least 10 of 11 subjects with this diagnosis compared to matched non-abusers (P<0.007, X2test); or 2) the difference in the mean abuser/non-abuser ratio for the gene from value of 1.0 was significant at P<0.05 (one sample t-test). In subjects with a history of alcohol abuse or dependence, 163 genes were changed significantly.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_001079866.1	NP_001073335.1	NC_000002.10 range: 219232622..219236409
NM_004328.4	NP_004319.1	NC_000002.10 range: 219232622..219236409

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0005739	mitochondrion	Cellular Component	IEA
GO:0005743	mitochondrial inner membrane	Cellular Component	IEA
GO:0005750	mitochondrial respiratory chain complex III	Cellular Component	TAS (9878253)
GO:0016020	membrane	Cellular Component	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0017111	nucleoside-triphosphatase activity	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0007605	sensory perception of sound	Biological Process	IEA
GO:0015980	energy derivation by oxidation of organic compounds	Biological Process	TAS (9878253)
GO:0006461	protein complex assembly	Biological Process	TAS (9878253)

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000074582

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: