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Gene Information
Gene ID:617
Symbol:BCS1L
Full Name:BCS1-like (yeast)
Alias:BCS|BCS1|BJS|FLNMS|GRACILE|Hs.6719|PTD|h-BCS
Organism:Homo sapiens (Human)
Chromosome:2
Genetic Location:2q33
Physical Location:219232622-219236409 on NC_000002.10
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:AF038195
Fold Change:0.72
P Value:0.013
Dataset Information
Name:12774316
Method:Microarray
Tissue:Temporal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed
Summary:To identify candidate mechanisms for alcohol abuse, the expression of 12,626 genes was measured in postmortem temporal cortex from 11 subjects with a history of alcohol abuse or dependence, with or without other psychiatric diagnoses and compared pairwise with the expression in 11 nonalcoholic subjects matched for the other psychiatric diagnoses and demographics. Genes were defined to have altered expression in alcohol abuse if: 1) the gene showed decreased expression in at least 10 of 11 subjects with alcohol abuse, or showed increased expression in at least 10 of 11 subjects with this diagnosis compared to matched non-abusers (P<0.007, X2test); or 2) the difference in the mean abuser/non-abuser ratio for the gene from value of 1.0 was significant at P<0.05 (one sample t-test). In subjects with a history of alcohol abuse or dependence, 163 genes were changed significantly.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_001079866.1NP_001073335.1NC_000002.10 range: 219232622..219236409
NM_004328.4NP_004319.1NC_000002.10 range: 219232622..219236409
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0016021integral to membraneCellular ComponentIEA
GO:0005739mitochondrionCellular ComponentIEA
GO:0005743mitochondrial inner membraneCellular ComponentIEA
GO:0005750mitochondrial respiratory chain complex IIICellular ComponentTAS (9878253)
GO:0016020membraneCellular ComponentIEA
GO:0000166nucleotide bindingMolecular FunctionIEA
GO:0017111nucleoside-triphosphatase activityMolecular FunctionIEA
GO:0005524ATP bindingMolecular FunctionIEA
GO:0007605sensory perception of soundBiological ProcessIEA
GO:0015980energy derivation by oxidation of organic compoundsBiological ProcessTAS (9878253)
GO:0006461protein complex assemblyBiological ProcessTAS (9878253)
Other Database Cross Links
NCBI Entrez Gene:617
HGNC:1020
Ensembl:ENSG00000074582
MIM:603647
HPRD:04708
HuGE Navigator:617
dbSNP:BCS1L
GeneCard:BCS1L
AceView:BCS1L