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Gene Information
Gene ID:460
Symbol:ASTN1
Full Name:astrotactin 1
Alias:ASTN|KIAA1747
Organism:Homo sapiens (Human)
Chromosome:1
Genetic Location:1q25.2
Physical Location:175096825-175400646 on NC_000001.9, complement
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:AB006627
Fold Change:0.73
P Value:0.0034
Dataset Information
Name:12774316
Method:Microarray
Tissue:Temporal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed
Summary:To identify candidate mechanisms for alcohol abuse, the expression of 12,626 genes was measured in postmortem temporal cortex from 11 subjects with a history of alcohol abuse or dependence, with or without other psychiatric diagnoses and compared pairwise with the expression in 11 nonalcoholic subjects matched for the other psychiatric diagnoses and demographics. Genes were defined to have altered expression in alcohol abuse if: 1) the gene showed decreased expression in at least 10 of 11 subjects with alcohol abuse, or showed increased expression in at least 10 of 11 subjects with this diagnosis compared to matched non-abusers (P<0.007, X2test); or 2) the difference in the mean abuser/non-abuser ratio for the gene from value of 1.0 was significant at P<0.05 (one sample t-test). In subjects with a history of alcohol abuse or dependence, 163 genes were changed significantly.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_004319.1NP_004310.1NC_000001.9 range: 175096825..175400646, complement
NM_207108.1NP_996991.1NC_000001.9 range: 175096825..175400646, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005575cellular_componentCellular ComponentND
GO:0016020membraneCellular ComponentIEA
GO:0016021integral to membraneCellular ComponentIEA
GO:0005515protein bindingMolecular FunctionIEA
GO:0007155cell adhesionBiological ProcessIEA
GO:0007158neuron adhesionBiological ProcessNAS
GO:0016477cell migrationBiological ProcessNAS
Other Database Cross Links
NCBI Entrez Gene:460
HGNC:773
Ensembl:ENSG00000152092
MIM:600904
HPRD:09019
HuGE Navigator:460
dbSNP:ASTN1
GeneCard:ASTN1
AceView:ASTN1