ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

GTF2A2

Full Name:

general transcription factor IIA, 2, 12kDa

Alias:

HsT18745|TF2A2|TFIIA

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

15q22.2

Physical Location:

57718357-57736986 on NC_000015.8, complement

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 235459 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		12774316
Method:		Microarray
Tissue:		Temporal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed
Summary:		To identify candidate mechanisms for alcohol abuse, the expression of 12,626 genes was measured in postmortem temporal cortex from 11 subjects with a history of alcohol abuse or dependence, with or without other psychiatric diagnoses and compared pairwise with the expression in 11 nonalcoholic subjects matched for the other psychiatric diagnoses and demographics. Genes were defined to have altered expression in alcohol abuse if: 1) the gene showed decreased expression in at least 10 of 11 subjects with alcohol abuse, or showed increased expression in at least 10 of 11 subjects with this diagnosis compared to matched non-abusers (P<0.007, X2test); or 2) the difference in the mean abuser/non-abuser ratio for the gene from value of 1.0 was significant at P<0.05 (one sample t-test). In subjects with a history of alcohol abuse or dependence, 163 genes were changed significantly.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_004492.1	NP_004483.1	NC_000015.8 range: 57718357..57736986, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IEA
GO:0005654	nucleoplasm	Cellular Component	EXP (1939271\|2449431\|8946909)
GO:0005672	transcription factor TFIIA complex	Cellular Component	NAS (7958900)
GO:0003700	transcription factor activity	Molecular Function	NAS (7724559)
GO:0042802	identical protein binding	Molecular Function	IPI (8626665)
GO:0003702	RNA polymerase II transcription factor activity	Molecular Function	IEA
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	NAS (7958899)
GO:0006367	transcription initiation from RNA polymerase II promoter	Biological Process	EXP (8946909)
GO:0006367	transcription initiation from RNA polymerase II promoter	Biological Process	IEA
GO:0006368	RNA elongation from RNA polymerase II promoter	Biological Process	EXP (9405375)
GO:0006350	transcription	Biological Process	IEA