ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Gtf2a2

Full Name:

general transcription factor II A, 2

Alias:

12kDa|TfIIg

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

9 D

Physical Location:

69860356-69870653 on NC_000075.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 2958 Symbol (Name): GTF2A2 (general transcription factor IIA, 2, 12kDa)

Ortholog Status:

The human GeneID 2958 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Gtf2a2
Original ID2:		AI851798

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_001039519.1	NP_001034608.1	NC_000075.5 range: 69860356..69870653

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IEA
GO:0005672	transcription factor TFIIA complex	Cellular Component	IEA
GO:0003702	RNA polymerase II transcription factor activity	Molecular Function	IEA
GO:0003743	translation initiation factor activity	Molecular Function	IEA
GO:0006350	transcription	Biological Process	IEA
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IEA
GO:0006367	transcription initiation from RNA polymerase II promoter	Biological Process	IEA