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Dataset Description
  • Dataset Name: 12774316
  • Species: Human
  • Method: Microarray
  • No. of Genes: 167
  • Tissue: Temporal cortex
  • Phenotype: Alcohol dependence (AD)/Alcohol abuse/Alcoholism
  • Publication: Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed
  • Dataset Summary: To identify candidate mechanisms for alcohol abuse, the expression of 12,626 genes was measured in postmortem temporal cortex from 11 subjects with a history of alcohol abuse or dependence, with or without other psychiatric diagnoses and compared pairwise with the expression in 11 nonalcoholic subjects matched for the other psychiatric diagnoses and demographics. Genes were defined to have altered expression in alcohol abuse if: 1) the gene showed decreased expression in at least 10 of 11 subjects with alcohol abuse, or showed increased expression in at least 10 of 11 subjects with this diagnosis compared to matched non-abusers (P<0.007, X2test); or 2) the difference in the mean abuser/non-abuser ratio for the gene from value of 1.0 was significant at P<0.05 (one sample t-test). In subjects with a history of alcohol abuse or dependence, 163 genes were changed significantly.

    Gene list of this dataset (167 genes)
    Page: 1 2 3 4 list all   
    GeneIDSymbolNameGenetic locationOriginal ID1Original ID2
    51669TMEM66transmembrane protein 668p12W26659 
    10724MGEA5meningioma expressed antigen 5 (hyaluronidase)10q24.1-q24.3AB014579 
    5962RDXradixin11q23N92548 
    22891ZNF365zinc finger protein 36510q21.2AB020651 
    10614HEXIM1hexamethylene bis-acetamide inducible 117q21.31AB021179 
    30836DNTTIP2deoxynucleotidyltransferase, terminal, interacting protein 21p22.1U15552 
    10542HBXIPhepatitis B virus x interacting protein1p13.3AF029890 
    26009ZZZ3zinc finger, ZZ-type containing 31p31.1AL080063 
    9884LRRC37Aleucine rich repeat containing 37A17q21.31H16917 
    91977MYOZ3myozenin 35q33.1AF052497 
        AF038194 
    3842TNPO1transportin 15q13.2AL049378 
    534ATP6V1G2ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G26p21.3W26326 
    9721GPRIN2G protein regulated inducer of neurite outgrowth 210q11.22AB011086 
    26045LRRTM2leucine rich repeat transmembrane neuronal 25q31.2AB007876 
    57240KIAA0484--AB007953 
    747DAGLAdiacylglycerol lipase, alpha11q12.2AB014559 
    711C3orf51chromosome 3 open reading frame 51-U88965 
    81611ANP32Eacidic (leucine-rich) nuclear phosphoprotein 32 family, member E1q21.2W25866 
    9699RIMS2regulating synaptic membrane exocytosis 28q22.3AB018294 
    26135SERBP1SERPINE1 mRNA binding protein 11p31AL080119 
        S80864 
    4609MYCv-myc myelocytomatosis viral oncogene homolog (avian)8q24.21M13929 
    Page: 1 2 3 4 list all