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Dataset Description
  • Dataset Name: 12774316
  • Species: Human
  • Method: Microarray
  • No. of Genes: 167
  • Tissue: Temporal cortex
  • Phenotype: Alcohol dependence (AD)/Alcohol abuse/Alcoholism
  • Publication: Sokolov et al. J Neurosci Res. (2003) Transcription profiling reveals mitochondrial, ubiquitin and signaling systems abnormalities in postmortem brains from subjects with a history of alcohol abuse or dependence. PubMed
  • Dataset Summary: To identify candidate mechanisms for alcohol abuse, the expression of 12,626 genes was measured in postmortem temporal cortex from 11 subjects with a history of alcohol abuse or dependence, with or without other psychiatric diagnoses and compared pairwise with the expression in 11 nonalcoholic subjects matched for the other psychiatric diagnoses and demographics. Genes were defined to have altered expression in alcohol abuse if: 1) the gene showed decreased expression in at least 10 of 11 subjects with alcohol abuse, or showed increased expression in at least 10 of 11 subjects with this diagnosis compared to matched non-abusers (P<0.007, X2test); or 2) the difference in the mean abuser/non-abuser ratio for the gene from value of 1.0 was significant at P<0.05 (one sample t-test). In subjects with a history of alcohol abuse or dependence, 163 genes were changed significantly.

    Gene list of this dataset (167 genes)
    Page: 1 2 3 4 list all   
    GeneIDSymbolNameGenetic locationOriginal ID1Original ID2
    8851CDK5R1cyclin-dependent kinase 5, regulatory subunit 1 (p35)17q11.2X80343 
    6792CDKL5cyclin-dependent kinase-like 5Xp22X89059 
    2323FLT3LGfms-related tyrosine kinase 3 ligand19q13.3U03858 
    23616SH3BP1SH3-domain binding protein 122q13.1Z83844 
    2212FCGR2AFc fragment of IgG, low affinity IIa, receptor (CD32)1q23M31932 
    2099ESR1estrogen receptor 16q25.1X03635 
    958CD40CD40 molecule, TNF receptor superfamily member 520q12-q13.2X60592 
    10692RRHretinal pigment epithelium-derived rhodopsin homolog4q25AF012270 
    3068HDGFhepatoma-derived growth factor (high-mobility group protein 1-like)1q21-q23D16431 
    6944VPS72vacuolar protein sorting 72 homolog (S. cerevisiae)1q21D43642 
    5936RBM4RNA binding motif protein 411q13U89505 
    546ATRXalpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae)Xq13.1-q21.1U72936 
    546ATRXalpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae)Xq13.1-q21.1U72936 
    1660DHX9DEAH (Asp-Glu-Ala-His) box polypeptide 91q25L13848 
    1665DHX15DEAH (Asp-Glu-Ala-His) box polypeptide 154p15.3AB001636 
    1466CSRP2cysteine and glycine-rich protein 212q21.1U57646 
    1465CSRP1cysteine and glycine-rich protein 11q32M33146 
    86ACTL6Aactin-like 6A3q26.33AF041474 
    2290FOXG1forkhead box G114q13X74142 
    2958GTF2A2general transcription factor IIA, 2, 12kDa15q22.2U14193 
    3298HSF2heat shock transcription factor 26q22.31M65217 
    3475IFRD1interferon-related developmental regulator 17q22-q31Y10313 
    7050TGIF1TGFB-induced factor homeobox 118p11.3X89750 
    10151HNRNPA3P1heterogeneous nuclear ribonucleoprotein A3 pseudogene 110q11.21S63912 
    3183HNRNPCheterogeneous nuclear ribonucleoprotein C (C1/C2)14q11.2M16342 
    1933EEF1B2eukaryotic translation elongation factor 1 beta 22q33-q34X60489 
    8467SMARCA5SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 54q31.1-q31.2AB010882 
    8725C19orf2chromosome 19 open reading frame 219q12AB006572 
    8405SPOPspeckle-type POZ protein17q21.33AJ000644 
    8099CDK2AP1CDK2-associated protein 112q24.31AF006484 
    730092LOC730092-16p12.1AF001549 
    9203ZMYM3zinc finger, MYM-type 3Xq13.1X95808 
    4781NFIBnuclear factor I/B9p24.1U70862 
    7644ZNF91zinc finger protein 9119p13.1-p12L11672 
    4862NPAS2neuronal PAS domain protein 22q11.2U77970 
    3110MNX1motor neuron and pancreas homeobox 17q36U07664 
    27287VENTXVENT homeobox homolog (Xenopus laevis)10q26.3AF068006 
    22936ELL2elongation factor, RNA polymerase II, 25q15U88629 
    6433SFRS8splicing factor, arginine/serine-rich 8 (suppressor-of-white-apricot homolog, Drosophila)12q24.33U08377 
    374868ATP9BATPase, class II, type 9B18q23AJ006268 
    3156HMGCR3-hydroxy-3-methylglutaryl-Coenzyme A reductase5q13.3-q14M11058 
    460ASTN1astrotactin 11q25.2AB006627 
    1806DPYDdihydropyrimidine dehydrogenase1p22U20938 
    10309CCNOcyclin O5p15.2-p13.1X52486 
    4836NMT1N-myristoyltransferase 117q21.31AF043324 
    2593GAMTguanidinoacetate N-methyltransferase19p13.3AC005329 
    5264PHYHphytanoyl-CoA 2-hydroxylase10pter-p11.2AF023462 
    2632GBE1glucan (1,4-alpha-), branching enzyme 1 (glycogen branching enzyme, Andersen disease, glycogen storage disease type IV)3p12.3L07956 
    2923PDIA3protein disulfide isomerase family A, member 315q15Z49835 
    23163GGA3golgi associated, gamma adaptin ear containing, ARF binding protein 317q25.1D63876 
    Page: 1 2 3 4 list all