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Gene Information
Gene ID:10979
Full Name:fermitin family homolog 2 (Drosophila)
Organism:Homo sapiens (Human)
Genetic Location:14q22.2
Physical Location:52393742-52487459 on NC_000014.7, complement
Gene Type:protein-coding
Orthologs:This gene has Rat: 289992 ortholog(s) in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Z24725
Fold Change:2.35
Dataset Information
Tissue:Prefrontal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Iwamoto et al. Neurosci Res. (2004) Decreased expression of NEFH and PCP4/PEP19 in the prefrontal cortex of alcoholics. PubMed
Summary:We have performed oligonucleotide microarray analysis in postmortem prefrontal cortices of alcoholics. Among about 12,000 genes represented on microarray, a total of 79 genes showed differential expression changes in alcoholics compared with control subjects, consisting of 54 up- and 25 down-regulated genes.
Gene Information
Original ID1:Hs.509343
Note:"Class II, down-regulated gene"
Dataset Information
Tissue:Frontal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_006832.1NP_006823.1NC_000014.7 range: 52393742..52487459, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0001725stress fiberCellular ComponentNAS
GO:0005737cytoplasmCellular ComponentIEA
GO:0005856cytoskeletonCellular ComponentIEA
GO:0005515protein bindingMolecular FunctionNAS
GO:0007155cell adhesionBiological ProcessNAS
GO:0008360regulation of cell shapeBiological ProcessIEA
GO:0030036actin cytoskeleton organization and biogenesisBiological ProcessNAS
Other Database Cross Links
NCBI Entrez Gene:10979
HuGE Navigator:10979