ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

PIK3R2

Full Name:

phosphoinositide-3-kinase, regulatory subunit 2 (beta)

Alias:

P85B|p85|p85-BETA

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

19q13.2-q13.4

Physical Location:

18125015-18142342 on NC_000019.8

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 18709 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		X80907
Fold Change:		-2.01

Dataset Information

Name:		15236863
Method:		Microarray
Tissue:		Prefrontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Iwamoto et al. Neurosci Res. (2004) Decreased expression of NEFH and PCP4/PEP19 in the prefrontal cortex of alcoholics. PubMed
Summary:		We have performed oligonucleotide microarray analysis in postmortem prefrontal cortices of alcoholics. Among about 12,000 genes represented on microarray, a total of 79 genes showed differential expression changes in alcoholics compared with control subjects, consisting of 54 up- and 25 down-regulated genes.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_005027.2	NP_005018.1	NC_000019.8 range: 18125015..18142342

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005622	intracellular	Cellular Component	IEA
GO:0005829	cytosol	Cellular Component	EXP (12660731)
GO:0005942	phosphoinositide 3-kinase complex	Cellular Component	IEA
GO:0005515	protein binding	Molecular Function	IPI (12029088)
GO:0016303	1-phosphatidylinositol-3-kinase activity	Molecular Function	ISS
GO:0035014	phosphoinositide 3-kinase regulator activity	Molecular Function	IEA
GO:0007165	signal transduction	Biological Process	IEA
GO:0019987	negative regulation of anti-apoptosis	Biological Process	ISS